NCT05797818 is a Phase 1, PHASE2 clinical trial of Methylene Blue Only in Healthcare Associated Infection, sponsored by Ondine Biomedical Inc..

Who is sponsoring NCT05797818?

NCT05797818 is sponsored by Ondine Biomedical Inc..

What drugs are being tested in NCT05797818?

Interventions in NCT05797818: Methylene Blue Only, Chlorhexidine Gluconate Only, Methylene Blue + Chlorhexidine Gluconate, Light Only.

What condition does NCT05797818 study?

NCT05797818 studies Healthcare Associated Infection, Nosocomial Infection, Surgical Site Infection.

Is NCT05797818 still recruiting?

NCT05797818 is currently completed. Last updated 4 April 2023.

Last reviewed 2023-04-04 · How we verify

NCT05797818

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Red Light Photobiomodulation and Topical Disinfectants

Completed Phase 1, PHASE2 Last updated 4 April 2023

What this trial tests

Phase 1, PHASE2 trial testing Methylene Blue Only in Healthcare Associated Infection in 28 participants. Completed in 8 February 2023.

Timeline

10 January 2023

Primary endpoint
8 February 2023

8 February 2023

Quick facts

Lead sponsor	Ondine Biomedical Inc.
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	basic science
Enrollment	28
Start date	10 January 2023
Primary completion	8 February 2023
Estimated completion	8 February 2023
Sites	1 location across United States

Drugs / interventions tested

Methylene Blue Only
Chlorhexidine Gluconate Only
Methylene Blue + Chlorhexidine Gluconate
Light Only

Conditions studied

Healthcare Associated Infection — all drugs for Healthcare Associated Infection →
Nosocomial Infection — all drugs for Nosocomial Infection →
Surgical Site Infection — all drugs for Surgical Site Infection →

Sponsor

Ondine Biomedical Inc. — full company profile →

Who can join

18 and older, any sex, with Healthcare Associated Infection or Nosocomial Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to evaluate the potential effects of photobiomodulation when used with topical disinfectants in the anterior nares of healthy adults. Over a three week period, participants will have their anterior nares swabbed with methylene blue, chlorhexidine gluconate, or a combination of the two followed by 4 minutes of non-thermal red light treatment. The fourth week of consist of only red light treatment. Culture samples of the subjects nasal microbiome will be taken prior to treatment, immediately after treatment, 4-, 8-, 24-, and 48 hours after treatment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Antimicrobial Resistance: The Answers.
Millar BC, Cates MJ, Torrisi MS, Round AJ, et al · · 2026 · PMID 41727556 · DOI 10.3389/bjbs.2026.15559

Verify or expand the search:

Other recruiting trials for Healthcare Associated Infection

Currently open trials in the same condition.

NCT06420934 — Surgical Handwashing: Drying With One or Two Surgical Towels · NA · recruiting
NCT06739863 — Evaluation of Healthcare Waste Management Practices and Problems Among Primary and Secondary Hospitals · active not recruiting
NCT05979545 — EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics · Phase 4 · recruiting
NCT06155747 — Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt) · recruiting
NCT05612672 — Evaluation of GeoHAI Implementation · NA · recruiting

Other Ondine Biomedical Inc. trials

Trials by the same sponsor.

NCT07189858 — Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada · NA · active not recruiting
NCT06702878 — Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections · Phase 3 · active not recruiting
NCT05090657 — Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures · Phase 2 · completed
NCT05184205 — Photodynamic Therapy for COVID-19 Prevention · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05797818 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ondine Biomedical Inc.
Last refreshed: 4 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05797818.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing