NCT05796817: ROCC

Reducing Oxygen Consumption in Critical Care

Completed Last updated 13 November 2023

What this trial tests

trial testing Ventilator modification in Mechanical Ventilation Complication in 12 participants. Completed in 10 October 2023.

Timeline

25 May 2023

Primary endpoint
10 October 2023

10 October 2023

Quick facts

Lead sponsor	Royal Brompton & Harefield NHS Foundation Trust
Status	Completed
Study type	OBSERVATIONAL
Enrollment	12
Start date	25 May 2023
Primary completion	10 October 2023
Estimated completion	10 October 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

• Ventilator modification

Conditions studied

• Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →

Sponsor

Royal Brompton & Harefield NHS Foundation Trust

Who can join

18 and older, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In normal practice oxygen supply can be easily met with existing hospital infrastructure. COVID - 19 however results in lung damage which greatly increases the amount of oxygen patients require - as a consequence some hospitals in the UK and other countries had situations where there was not enough oxygen for their inpatients.

COVID - 19 has caused many more patients to requiring assistance with their breathing using a ventilator. Due to the limited supply of sophisticated ventilators that 're-use' oxygen patients breathe out, some hospitals have used ventilators normally used by patients at home (domiciliary ventilators). Whilst these are inexpensive and commonly available, any oxygen the patient breathes out is simply released into the atmosphere.

The address this problem, and in turn reduce the oxygen demand on hospital infrastructure the biomedical engineering team (BME) at the Royal Brompton Hospital, London devised a simple 3-D printed modification which captures and reuses oxygen on commonly used domiciliary ventilators. Laboratory testing found this modification can increase the oxygen given by the ventilator without increasing the oxygen consumption of the ventilator - effectively reducing oxygen demand on hospital infrastructure.

This study will evaluate this modification in patients admitted to intensive care requiring assistance with their breathing. This will involve measuring oxygen levels on domiciliary ventilators (Breas Nippy 4+, ResMed Lumis 150 or Vivo 1, 2 or 3) with and without the modification and with small increases in oxygen supplied to the patient for a total study period of 2 hours.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.