Last reviewed · How we verify
NCT05795569: FIRST
Removal of Nasogastric Feeding Tube Post Extubation in ICU : a Prospective Randomized Trial
NA trial testing Nasogastric Tube removal during extubation in Deglutition Disorders in 112 participants. Completed in 10 April 2025.
10 April 2025
Quick facts
| Lead sponsor | Centre Hospitalier Régional d'Orléans |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 112 |
| Start date | 21 March 2023 |
| Primary completion | 10 April 2025 |
| Estimated completion | 10 April 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Nasogastric Tube removal during extubation
- Yale Swallow Protocol
- Classif Nasogastric Tube Management
- Classic swallowing test
Conditions studied
- Deglutition Disorders — all drugs for Deglutition Disorders →
- Intensive Care Unit Syndrome — all drugs for Intensive Care Unit Syndrome →
- Swallowing Disorder — all drugs for Swallowing Disorder →
- Feeding or Eating Disorder — all drugs for Feeding or Eating Disorder →
Sponsor
Centre Hospitalier Régional d'Orléans
Who can join
18 and older, any sex, with Deglutition Disorders or Intensive Care Unit Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Post-extubation dysphagia (PED) is a frequent but still underestimated condition in the intensive care units (ICU). In the international literature, the manifestations and consequences of PED lead to intra- and post-intensive care comorbidities. The exact etiology of PED is unknown, but considered multifactorial. Numerous causes, acquired during ICU, can lead to a delay in the reintroduction of intravenous nutrition, or even favor the development of inhalation pneumopathy. One of these causes is the presence of the nasogastric tube. The incidence of ECD varies from 3 to 62%. Its presence impacts morbidity and mortality. Preventive strategies for PED have only been studied with questionable methodologies. The goal of ICU therapists is to detect PED as early as possible in order to implement curative strategies such as adapted nutrition and early swallowing rehabilitation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05795569
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Centre Hospitalier Régional d'Orléans trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05795569 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Régional d'Orléans
- Last refreshed: 30 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05795569.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing