65 and older, any sex, with Hypertension. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Time to Dementia OnsetPrimary· Median follow up times: 1) 298 days (exp), 249 days (ref) 2) 995 days (exp), 981 days (ref) 3) 515 days (exp), 448 days (ref) 4) 307 days (exp), 253 days (ref)
Time to dementia onset, i.e., Alzheimer's disease, vascular dementia, senile, presenile, or unspecified dementia, or dementia in other diseases classified elsewhere. Please refer to uploaded protocol for full definition due to size limitations.
Analysis 1
Group
Value
95% CI
Propranolol or Carvedilol
22.96
22.48 – 23.45
Atenolol, Bisoprolol or Sotalol
19.84
19.35 – 20.33
Analysis 2
Group
Value
95% CI
Propranolol or Carvedilol
26.82
26.22 – 27.44
Atenolol, Bisoprolol or Sotalol
25.84
25.25 – 26.45
Analysis 3
Group
Value
95% CI
Propranolol or Carvedilol
23.03
22.47 – 23.60
Atenolol, Bisoprolol or Sotalol
20.21
19.64 – 20.79
Analysis 4
Group
Value
95% CI
Propranolol or Carvedilol
7.21
6.95 – 7.49
Atenolol, Bisoprolol or Sotalol
6.47
6.20 – 6.75
Sponsor's own description
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 10 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05794997.