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NCT05791851: HBR2
Heplisav-B Revaccination for Hepatitis B Vaccine Nonresponders
trial in HIV Infections in 31 participants. Completed in 14 June 2022.
14 June 2022
Quick facts
| Lead sponsor | University of Maryland, Baltimore |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 31 |
| Start date | 23 October 2019 |
| Primary completion | 14 June 2022 |
| Estimated completion | 14 June 2022 |
| Sites | 2 locations across United States |
Conditions studied
- HIV Infections — all drugs for HIV Infections →
- Hepatitis B — all drugs for Hepatitis B →
- Vaccine Response Impaired — all drugs for Vaccine Response Impaired →
Sponsor
University of Maryland, Baltimore
Who can join
Adults 18 to 109, any sex, with HIV Infections or Hepatitis B. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this natural history study is to examine the immune responses to the Heplisav-B vaccine in Veterans living with HIV who were non-responders to prior HBV vaccination. A comparison group of HBV vaccine nonresponders without HIV infection will be enrolled to characterize the HIV-associated immune alterations that affect vaccine response. The investigators hypothesize that TLR9-mediated innate immune stimulation with Heplisav will elicit HBV seroprotection despite prior vaccination failures in persons living with HIV, compared to HIV uninfected individuals. Participants eligible for Heplisav-B vaccination will be asked to provide blood samples at multiple timepoints before and after their vaccination.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05791851
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05791851 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Maryland, Baltimore
- Last refreshed: 30 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05791851.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing