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NCT05786521

Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

Completed Phase 4 Results posted Last updated 4 May 2025
What this trial tests

Phase 4 trial testing Semaglutide Injectable Product in Aging in 20 participants. Completed in 20 May 2024.

Timeline
1 April 2023
Primary endpoint
20 May 2024
20 May 2024

Quick facts

Lead sponsorThe University of Texas Health Science Center at San Antonio
PhasePhase 4
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposebasic science
Enrollment20
Start date1 April 2023
Primary completion20 May 2024
Estimated completion20 May 2024
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

The University of Texas Health Science Center at San Antonio

Who can join

Adults 65 to 90, any sex, with Aging or Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Lean Body Mass Change Primary · Baseline to 20 weeks

Determine if there is any change in lean body mass

GroupValue95% CI
Semaglutide and Lifestyle Intervention-1730.6-3063 – -398
Lifestyle Intervention-421-1745 – 911

Adverse events — posted to ClinicalTrials.gov

Time frame: 20 weeks. Reporting threshold: 5%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Semaglutide and Lifestyle Intervention
Serious: 0/10 (0%)
Deaths: 0/10
Lifestyle Intervention
Serious: 0/10 (0%)
Deaths: 0/10
Other adverse events (1 terms — click to expand)

ReactionSystemSemaglutide and Lifestyle …Lifestyle Intervention
Abdominal painGastrointestinal disorders

Data from ClinicalTrials.gov NCT05786521 adverse events section.

Sponsor's own description

Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management. This new study will help find out what effects, semaglutide has on people who take the drug and the drug's effect on physical function, body composition, and aging.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial.
    Cortes TM, Vasquez L, Serra MC, Robbins R, et al · · 2024 · cited 10× · PMID 39269759 · DOI 10.2196/62667
  2. GLP-1 receptor agonists in the context of cancer: the road ahead.
    Miousse IR. · · 2025 · cited 6× · PMID 40285503 · DOI 10.1152/ajpcell.00245.2025
  3. Impact of Incretin-Based Therapy on Skeletal Muscle Health.
    Koceva A, Janež A, Jensterle M. · · 2025 · cited 3× · PMID 41011082 · DOI 10.3390/medicina61091691
  4. Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial <i>post hoc</i> analysis.
    Dinkla L, Beavers KM, Robbins R, Akpalu D, et al · · 2025 · PMID 41393101 · DOI 10.3389/fragi.2025.1691007

Verify or expand the search:

Other trials of Semaglutide Injectable Product

Trials testing the same drug.

Other recruiting trials for Aging

Currently open trials in the same condition.

Other The University of Texas Health Science Center at San Antonio trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05786521.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing