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NCT05781945
COVID-19 Pneumonia and Gut Inflammation
NA trial testing probiotics in Inflammation in 80 participants. Completed in 1 May 2022.
31 January 2022
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 80 |
| Start date | 1 March 2021 |
| Primary completion | 31 January 2022 |
| Estimated completion | 1 May 2022 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- probiotics — full drug profile →
- standard therapy — full drug profile →
Conditions studied
- Inflammation — all drugs for Inflammation →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
18 and older, any sex, with Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of our study was to evaluate the efficacy of a mix of three probiotic strains (Bifidobacterium lactis LA 304, Lactobacillus salivarius LA 302, and Lactobacillus acidophilus LA 201; Lactibiane Iki®) in the reduction in fecal calprotectin in patients with COVID-19 pneumonia, compared to a control group. The secondary aim was to evaluate the reduction in oxygen support and length of hospital stay in patients taking the probiotic mix.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens.
Raj ST, Bruce AW, Anbalagan M, Srinivasan H, et al · · 2024 · cited 19× · PMID 38863829 · DOI 10.3389/fcimb.2024.1384939
Verify or expand the search:
- PubMed search for NCT05781945
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05781945 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 23 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05781945.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing