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BALCoS - Basel Long COVID Cohort Study and DiLCoS - Digital Long COVID Substudy (BALCoS/DiLCoS)
The Basel Long COVID Cohort Study (BALCoS) is a registry-based cohort study that focuses on the patients' present health status, symptoms, the course of these symptoms, and potential mechanisms involved. The project aims to investigate proposed mechanisms behind Post COVID-19 condition (PCC), including a) autoimmunity, b) chronic inflammation, c) genetics, d) coagulation disorders, and e) psychosocial factors. Patients in the cohort can also join the Digital Long COVID Study (DiLCoS), a single-arm, cohort-based proof-of-feasibility study that is part of the larger BALCoS. DiLCoS is a intervention substudy designed to evaluate whether doing exercises delivered via a smartphone app (referred as digital intervention) can help with PCC. The digital intervention is a 12-week program that includes different kinds of exercises like breathing exercises, relaxation techniques, and tips on managing fatigue and other symptoms. It also teaches patients how to monitor their activities and energy levels, and provides psychological exercises to cope with negative thoughts and pain. Patients in the cohort complete a set of assessments that include the collection of sociodemographic and clinical data, biomarkers, neurocognitive testing, psychometric questionnaires, and measures of physical performance, and provide consent that their data from routine clinical care can be used for the study.
Details
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 120 |
| Start date | 2023-04-20 |
| Completion | 2026-04 |
Conditions
- Post COVID-19 Condition (PCC)
Interventions
- Digital intervention (DiLCoS)
- Data collection
Primary outcomes
- Change in World Health Organization Disability Assessment Schedule (WHODAS 2.0) (12- item version) — At Baseline, T1 (BL + 3 months), T2 (BL + 6 months); T3 (BL + 12 months)
The World Health Organization Disability Assessment Schedule (WHODAS 2.0) assesses and classifies disability due to health problems during the past 4 weeks. This study will utilize the 12- item version. Items are answered on a 5-point scale ranging from 0 = "none" to 4 = "extreme or cannot do".
Countries
Switzerland