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NCT05778110: MOSS-THINK
Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue
trial testing Type of disease in Brain Injury Traumatic Severe in 10 participants. Status unknown.
31 March 2024
Quick facts
| Lead sponsor | RenJi Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 1 April 2023 |
| Primary completion | 31 March 2024 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across China |
Drugs / interventions tested
- Type of disease
Conditions studied
- Brain Injury Traumatic Severe — all drugs for Brain Injury Traumatic Severe →
- Intracranial Hemorrhage, Hypertensive — all drugs for Intracranial Hemorrhage, Hypertensive →
Sponsor
RenJi Hospital
Who can join
Adults 16 to 65, any sex, with Brain Injury Traumatic Severe or Intracranial Hemorrhage, Hypertensive. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is: * Which RNA, protein and metabolites are differently expressed in lesion tissues? * What molecular mechanism is participated in TBI or ICH? Participants will be treated by emergency operation, and their lesion tissues will be collected during the operation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury.
Weng W, He Z, Ma Z, Huang J, et al · · 2025 · cited 32× · PMID 39496783 · DOI 10.1038/s41418-024-01408-0
Verify or expand the search:
- PubMed search for NCT05778110
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Type of disease
Trials testing the same drug.
- NCT05778123 — Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury · unknown
Other recruiting trials for Brain Injury Traumatic Severe
Currently open trials in the same condition.
- NCT06480838 — Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury · recruiting
- NCT04945213 — Biperiden Trial for Epilepsy Prevention · Phase 3 · recruiting
Other RenJi Hospital trials
Trials by the same sponsor.
- NCT07584733 — Biomarker-Enriched Kidney-Preserving Strategy With Disitamab Vedotin Plus Tislelizumab in HER2-Positive High-Risk Upper · Phase 2 · not yet recruiting
- NCT07537725 — EEG-TMS for Postoperative Delirium After Cardiac Surgery · NA · not yet recruiting
- NCT07527936 — A Study of BEN301 Injection in theTreatment of Autoimmune Diseases · EARLY_PHASE1 · not yet recruiting
- NCT07343076 — Efficacy of Immediate Versus Staged Complete Revascularization in Patients With NSTE-ACS and Multivessel Disease (FUTURE · NA · not yet recruiting
- NCT07449793 — Biochemical Response and Clinical Outcomes in Patients With PBC · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05778110 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by RenJi Hospital
- Last refreshed: 3 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05778110.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing