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NCT05775198
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
NA trial testing PBMC immunomodulated with IFNt in Infertility, Female in 300 participants. Currently enrolling.
13 March 2026
Quick facts
| Lead sponsor | Nadezhda Women's Health Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 1 March 2023 |
| Primary completion | 13 March 2026 |
| Estimated completion | 28 April 2026 |
| Sites | 1 location across Bulgaria |
Drugs / interventions tested
- PBMC immunomodulated with IFNt — full drug profile →
Conditions studied
- Infertility, Female — all drugs for Infertility, Female →
- IVF — all drugs for IVF →
Sponsor
Nadezhda Women's Health Hospital
Who can join
Adults 18 to 50, female only, with Infertility, Female or IVF. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy and live birth rates). To achieve this, blood will be obtained from eligible participants. Target cells will be isolated and incubated with the tested modulator for 24h, and returned to the uterine cavity 1 day prior to embryo transfer. Researchers will compare the reproductive outcome of the tested intervention to that of a control group who will not receive the investigated cell treatment prior to embryo transfer.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intrauterine Administration of PBMC Modulated with IFN-τ Before Embryo Transfer Improves Clinical Outcomes of IVF Patients-A Randomized Control Trial.
Ruseva M, Parvanov D, Ganeva R, Handzhiyska M, et al · · 2025 · PMID 41595597 · DOI 10.3390/biomedicines14010061
Verify or expand the search:
- PubMed search for NCT05775198
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Nadezhda Women's Health Hospital trials
Trials by the same sponsor.
- NCT05421364 — Effects of Intrauterine Administration of Autologous PBMC on the Endometrial Cells Populations · NA · recruiting
- NCT05775211 — Effects of Intrauterine Administration of Autologous PBMC Modulated With IFNt on Endometrial Cell Populations · NA · recruiting
- NCT05257213 — Heparin Solution Versus Anti-adhesion Barrier Gel for Intrauterine Adhesions Prevention After Operative Hysteroscopy · NA · recruiting
- NCT05161247 — Reproductive Outcome After Sperm Selection for Intracytoplasmic Sperm Injection (ICSI) Using Zona Pellucida Proteins · NA · completed
- NCT04797377 — Autologous Intraovarian Platelet Rich Plasma Treatment in Women With Poor Ovarian Response · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05775198 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nadezhda Women's Health Hospital
- Last refreshed: 21 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05775198.
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