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NCT05768906: (DIS)AGREE
(DIS)AGreement of Relatives Regarding Ethical End-of-life Decisions in ICU.
trial testing observational in Cessation of Treatment in 429 participants. Completed in 1 September 2025.
1 September 2025
Quick facts
| Lead sponsor | Société Française d'Anesthésie et de Réanimation |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 429 |
| Start date | 1 July 2023 |
| Primary completion | 1 September 2025 |
| Estimated completion | 1 September 2025 |
| Sites | 23 locations across France |
Drugs / interventions tested
- observational — full drug profile →
Conditions studied
- Cessation of Treatment — all drugs for Cessation of Treatment →
- End of Life — all drugs for End of Life →
Sponsor
Société Française d'Anesthésie et de Réanimation
Who can join
18 and older, any sex, with Cessation of Treatment or End of Life. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In the ICU, the vast majority of patients die following a life-sustaining therapies (LST) limitation decision. Most often, the patient is not able to express himself and has not made his wishes known beforehand, for example in the form of advance directives. The "relatives" are then the only recourse to state the patient's wishes, without any guarantee that they are aware of them. In France, the final decision is made by the physician (or the medical team) who is responsible for it. In this context, disagreements and even real legal conflicts on LST limitation decisions between relatives and physicians seem to be more and more frequent. To our knowledge, few data exist on the frequency of these disagreements over LST limitation decisions. The main objective of this study is to evaluate the frequency of disagreements between relatives and physicians over LST limitation decisions in adult intensive care.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05768906
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05768906 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Société Française d'Anesthésie et de Réanimation
- Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05768906.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing