LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)

NCT05765370 NA RECRUITING

To determine whether treating to an LDL-C target of 25 to \<70 mg/dL is superior to an LDL-C target of 70 to \<100 mg/dL with respect to major cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization) in patients aged ≥75 years with atherosclerotic cardiovascular disease (ASCVD). To determine whether treating to an LDL-C target of 25 to \<70 mg/dL is non-inferior to an LDL-C target of 70 to \<100 mg/dL with respect to major safety events (hemorrhagic stroke, new-onset diabetes, muscle-related events, neurocognitive adverse events, new or recurrent cancer, cataract, or hepatic disorder \[Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) \>3× ULN, or total bilirubin \>2× ULN\]) in patients aged ≥75 years with ASCVD.

Details

Lead sponsor	China National Center for Cardiovascular Diseases
Phase	NA
Status	RECRUITING
Enrolment	4200
Start date	Fri Mar 24 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Dec 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Atherosclerotic Cardiovascular Disease
• Older Patients
• LDL Cholesterol

Interventions

• Achieving a Target LDL-C level of 25mg/dL≤ LDL-C<70mg/dL
• Achieving a Target LDL-C level of 70mg/dL≤ LDL-C<100mg/dL

Countries

China