NCT05764304 is a Phase 3 clinical trial of Sinomenine in Knee Osteoarthritis, sponsored by Shanghai 6th People's Hospital.

Who is sponsoring NCT05764304?

NCT05764304 is sponsored by Shanghai 6th People's Hospital.

What drugs are being tested in NCT05764304?

Interventions in NCT05764304: Sinomenine, Glucocorticoid.

What condition does NCT05764304 study?

NCT05764304 studies Knee Osteoarthritis.

Is NCT05764304 still recruiting?

NCT05764304 is currently status unknown. Last updated 10 March 2023.

Last reviewed 2023-03-10 · How we verify

NCT05764304

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sinomenine Versus Glucocorticoid for Knee OA

Status unknown Phase 3 Last updated 10 March 2023

What this trial tests

Phase 3 trial testing Sinomenine in Knee Osteoarthritis in 328 participants. Status unknown.

Timeline

28 February 2023

Primary endpoint
27 February 2025

31 March 2025

Quick facts

Lead sponsor	Shanghai 6th People's Hospital
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	328
Start date	28 February 2023
Primary completion	27 February 2025
Estimated completion	31 March 2025

Drugs / interventions tested

Sinomenine — full drug profile →
Glucocorticoid — full drug profile →

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Shanghai 6th People's Hospital

Who can join

Adults 40 to 70, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Both glucocorticoid and sinomenine are widely used in the routine clinical treatment of osteoarthritis, but there is still a lack of high level of clinical evidence for the direct comparison of efficacy between the two drugs. This trial aims to evaluate whether intraarticular injection of sinomenine was noninferior to intraarticular injection of glucocorticoid for symptom relief in patients with early knee arthritis, and whether intraarticular injection of sinomenine was superior to intraarticular injection of glucocorticoid for changes in tibial cartilage volume (measured by mean thickness) from baseline compared with intraarticular injection of glucocorticoid. 326 people will participate in the study at 3 different research/medical institutions, with centres competing for inclusion. This trial was designed by random blind method. This trial will last for 2 years and participants will receive 6 injections every 4 months.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Redox regulation: mechanisms, biology and therapeutic targets in diseases.
Li B, Ming H, Qin S, Nice EC, et al · · 2025 · cited 104× · PMID 40050273 · DOI 10.1038/s41392-024-02095-6
Cartilage organoids bridging bench to bedside: A steroid-free strategy for early osteoarthritis repair.
Zhang X, Lin Z, Lv M, Lu C, et al · · 2026 · PMID 41560786 · DOI 10.1016/j.mtbio.2025.102688

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Shanghai 6th People's Hospital trials

Trials by the same sponsor.

NCT07482891 — An Exploratory Study on Efficacy and Safety of Fosaprepitant and Palonosetron Hydrochloride for Injection in Preventing · Phase 4 · not yet recruiting
NCT07414277 — CGM for Insulin-Treated T2DM During Post-Discharge Transition · NA · not yet recruiting
NCT07359053 — MAGNATE-S: Paclitaxel Polymer Micelles Combo in Advanced Sarcoma · Phase 2 · recruiting
NCT07288372 — The CGM-OGTT Glycemic Homeostasis Study · not yet recruiting
NCT06936657 — Intervention Effects of Optimized Carbohydrate Diet in Patients With Type 2 Diabetes · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05764304 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shanghai 6th People's Hospital
Last refreshed: 10 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05764304.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing