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NCT05762705
A Mobile Gaming App to Improve Adherence to PrEP
NA trial testing Multilevel Gaming Adherence Intervention in Medication Adherence in 200 participants. Currently enrolling.
3 March 2027
Quick facts
| Lead sponsor | Rhode Island Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 200 |
| Start date | 21 June 2024 |
| Primary completion | 3 March 2027 |
| Estimated completion | 3 March 2027 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Multilevel Gaming Adherence Intervention
- Treatment as Usual +
Conditions studied
- Medication Adherence — all drugs for Medication Adherence →
- HIV/AIDS — all drugs for HIV/AIDS →
Sponsor
Rhode Island Hospital
Who can join
Adults 15 to 34, any sex, with Medication Adherence or HIV/AIDS. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, the investigators will test the mobile game, Viral Combat, for efficacy and acceptability among diverse participants, ages 15-34 years, receiving PrEP care in clinical settings in New England and Mississippi. Formative evaluation interviews will be conducted with stakeholders (healthcare workers, clinic administrators, and patients taking PrEP) to inform intervention delivery. Data from the formative interviews will also be used to make necessary adaptations to the game and assess acceptability for diverse populations and clinics. Viral Combat will then be further tested with 200 participants ages 15-34 years, receiving PrEP care at clinical sites in the South (n=100 Jackson, MS) and New England (n=100, Providence, RI; Boston, MA) in a multisite Hybrid Type 1 effectiveness-implementation randomized controlled trial (RCT). This trial will test the efficacy of the intervention compared to a control condition (a non-PrEP related game) on biological and behavioral measures. At the end of the trial, a summative evaluation of the implementation context using the i-PARIHS framework will occur. These interviews with study participants and clinic staff will inform future implementation and dissemination of Viral Combat.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05762705
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
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Other Rhode Island Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05762705 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rhode Island Hospital
- Last refreshed: 14 May 2025
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