Last reviewed · How we verify
NCT05761314: 4218
Solid Tumors in RASopathies
NA trial testing Molecular characterization of solid tumor in RASopathies in RASopathy in 100 participants. Currently enrolling.
30 October 2023
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 100 |
| Start date | 12 October 2021 |
| Primary completion | 30 October 2023 |
| Estimated completion | 12 October 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Molecular characterization of solid tumor in RASopathies
Conditions studied
- RASopathy — all drugs for RASopathy →
- Costello Syndrome — all drugs for Costello Syndrome →
- Cardio-Facio-Cutaneous Syndrome — all drugs for Cardio-Facio-Cutaneous Syndrome →
- Noonan Syndrome — all drugs for Noonan Syndrome →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
Eligibility, any sex, with RASopathy or Costello Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic plasticity and neuronal growth. RASopathies are characterized by multi-organ involvement, growth delay, premature aging and haemato-oncological manifestations. Based on evidences provided by literature, cancer screening protocols are applied in some individuals affected by RASopathies, even though detailed information about prevalence and molecular pathogenesis of such tumors is still not clearly elucidate.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05761314
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for RASopathy
Currently open trials in the same condition.
- NCT07344480 — Retrospective Natural History Study of RASopathy-associated Cardiomyopathy (RAS-CM) · recruiting
- NCT06776380 — Pubertal Development in Patients with RASopathies · recruiting
- NCT06489067 — Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies (ECORAS2023) · recruiting
- NCT04888936 — Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies · recruiting
- NCT06331117 — Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies · NA · recruiting
Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials
Trials by the same sponsor.
- NCT07514572 — Impact of Estimated Weight and Height on Nutritional Assessment in Elderly · NA · not yet recruiting
- NCT07504679 — Adipose Visceral and Epicardial Risk Evaluation · NA · not yet recruiting
- NCT07520643 — MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling · not yet recruiting
- NCT07479238 — Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · not yet recruiting
- NCT07494227 — Development of the SC-IBD Self-Care Measurement Scale · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05761314 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 4 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05761314.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing