NCT05759481 (PONV) is a Phase 2 clinical trial of Propofol in Post-operative Nausea and Vomiting, sponsored by Milton S. Hershey Medical Center.

Who is sponsoring NCT05759481?

NCT05759481 is sponsored by Milton S. Hershey Medical Center.

What drugs are being tested in NCT05759481?

Interventions in NCT05759481: Propofol, Placebo.

What condition does NCT05759481 study?

NCT05759481 studies Post-operative Nausea and Vomiting.

Is NCT05759481 still recruiting?

NCT05759481 is currently completed. Last updated 2 April 2025.

Last reviewed 2025-04-02 · How we verify

NCT05759481: PONV

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Completed Phase 2 Last updated 2 April 2025

What this trial tests

Phase 2 trial testing Propofol in Post-operative Nausea and Vomiting in 68 participants. Completed in 12 March 2025.

Timeline

1 February 2024

Primary endpoint
12 March 2025

12 March 2025

Quick facts

Lead sponsor	Milton S. Hershey Medical Center
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	68
Start date	1 February 2024
Primary completion	12 March 2025
Estimated completion	12 March 2025
Sites	1 location across United States

Drugs / interventions tested

Propofol (Propofol) — full drug profile →
Placebo

Conditions studied

Post-operative Nausea and Vomiting — all drugs for Post-operative Nausea and Vomiting →

Sponsor

Milton S. Hershey Medical Center

Who can join

18 and older, any sex, with Post-operative Nausea and Vomiting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial.
Keck WL, Deng E, Liu WM, Kanekar R, et al · · 2026 · cited 1× · PMID 41593496 · DOI 10.1186/s12871-026-03649-7

Verify or expand the search:

Other trials of Propofol

Trials testing the same drug.

NCT07251101 — Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery · NA · not yet recruiting
NCT07294092 — Ketamine and Propofol NeuroImaging · EARLY_PHASE1 · recruiting
NCT07269808 — Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration · Phase 3 · recruiting
NCT07460050 — Comparison of Two Sedative Agents in Terms of Controlled Hypotension · NA · not yet recruiting
NCT07347496 — A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined · Phase 4 · not yet recruiting

Other Milton S. Hershey Medical Center trials

Trials by the same sponsor.

NCT05180552 — The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting · NA · withdrawn
NCT07461844 — Transdiagnostic Sleep and Circadian Treatment for Autistic Adults · NA · not yet recruiting
NCT06253858 — Ultrasound (US) Guided External Ventricular Catheter Placement · NA · not yet recruiting
NCT07225699 — IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING · NA · not yet recruiting
NCT07461168 — Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05759481 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Milton S. Hershey Medical Center
Last refreshed: 2 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05759481.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing