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NCT05750875
Gabapentin Versus Loratadine in Uremic Pruritus
Phase 4 trial testing Loratadine in Pruritus in 64 participants. Completed in 31 October 2022.
31 October 2022
Quick facts
| Lead sponsor | King Edward Medical University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 64 |
| Start date | 1 May 2022 |
| Primary completion | 31 October 2022 |
| Estimated completion | 31 October 2022 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Loratadine (loratadine) — full drug profile →
- Gabapentin (Gabapentin) — full drug profile →
Conditions studied
- Pruritus — all drugs for Pruritus →
- Uremia — all drugs for Uremia →
- Chronic Kidney Diseases — all drugs for Chronic Kidney Diseases →
Sponsor
King Edward Medical University
Who can join
Adults 18 to 70, any sex, with Pruritus or Uremia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the efficacy of gabapentin with loratadine in reducing the severity of uremic pruritus in patients of chronic kidney disease and to compare the side effects of both drugs. The main questions it aims to answer are: * Which drug (gabapentin versus loratadine) is more effective in reducing the severity of uremic pruritus? * Which drug (gabapentin versus loratadine) has fewer side effects? Participants were divided into two groups.Group A received loratadine 10mg daily and group B received gabapentin 100mg daily. Both groups were given treatment for 4 weeks. * Participants were asked to grade the severity of pruritus on a numerical rating scale and also answer the Dermatology Life Quality Index Questionnaire (DLQI) * Participants were also asked to report any side effects, if occurred. Researchers compared both groups with regards to improvement in pruritus severity, DLQI score and side effects.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05750875
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Currently open trials in the same condition.
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Other King Edward Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05750875 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King Edward Medical University
- Last refreshed: 16 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05750875.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing