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NCT05750771
Comparison of DCB and DES for Severe Calcification of de Novo Lesion in Elderly CHD
NA trial testing DES in Coronary Artery Disease in 218 participants. Completed in 1 August 2025.
1 August 2025
Quick facts
| Lead sponsor | Henan Institute of Cardiovascular Epidemiology |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 218 |
| Start date | 20 February 2023 |
| Primary completion | 1 August 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- DES
- DCB
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
Sponsor
Henan Institute of Cardiovascular Epidemiology
Who can join
60 and older, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial was to compare the effectiveness of drug balloons versus drug-coated stents in calcified lesions in elderly coronary artery disease. The main question it aims to answer is whether the application of DCB is non-inferior to DES for in situ large vessel calcified lesions in the elderly coronary arteries. And to develop a method to precisely identify the nature and extent of calcified lesions and to rationalize the choice of pretreatment.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Application of Drug-Coated Balloons in Complex High Risk and Indicated Percutaneous Coronary Interventions.
Somsen YBO, Rissanen TT, Hoek R, Ris TH, et al · · 2025 · cited 8× · PMID 39660933 · DOI 10.1002/ccd.31316 -
Drug-Coated Balloons: Recent Evidence and Upcoming Novelties.
Shahrori ZMF, Frazzetto M, Mahmud SH, Alghwyeen W, et al · · 2025 · cited 6× · PMID 40422965 · DOI 10.3390/jcdd12050194
Verify or expand the search:
- PubMed search for NCT05750771
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of DES
Trials testing the same drug.
- NCT06168422 — A Cohort Study of PCI Strategies for Severely Calcified Lesions of Complex Coronary Arteries in the Elderly · recruiting
- NCT04842838 — Comparative Clinical Study of Drug-coating Balloon Strategy and Drug-eluting Stent Strategy · NA · unknown
- NCT04859985 — The SELUTION DeNovo Study · NA · active not recruiting
- NCT03190473 — OPTIMIZE IDE for the Treatment of ACS · NA · terminated
- NCT03223974 — Clinical Trial on Safety and Efficacy of Drug-coated Balloon in Treatment of Coronary Bifurcation Lesions · NA · completed
Other recruiting trials for Coronary Artery Disease
Currently open trials in the same condition.
- NCT07399002 — LONG NAGOMI™ PMCF STUDY · recruiting
- NCT07420582 — Antegrade Autologous Blood Reinfusion After CPB · recruiting
- NCT07493603 — A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease · Phase 1, PHASE2 · recruiting
- NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
- NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting
Other Henan Institute of Cardiovascular Epidemiology trials
Trials by the same sponsor.
- NCT07514624 — CRIC Combined With MFT for MFR in Patients With Incomplete Revascularization of CAD · NA · not yet recruiting
- NCT06820970 — CRIC Combined With MFT for Cardiovascular Adverse Events in Patients With Incomplete Revascularization of CAD · NA · recruiting
- NCT06769256 — Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden · Phase 4 · recruiting
- NCT07181356 — Effects of Long-term Remote Ischemic Preconditioning on Clinical Outcome in Patients With Acute Myocardial Infarction · NA · recruiting
- NCT04308551 — Effect of Indobufen and Aspirin on Platelet Aggregation and Long Term Prognosis in Patients With Coronary Heart Disease · NA · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05750771 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Henan Institute of Cardiovascular Epidemiology
- Last refreshed: 6 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05750771.
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