Last reviewed · How we verify

NCT05750303

Potential Prognostic Markers of Recovery in Post-stroke Rehabilitation

Completed Last updated 1 March 2023
What this trial tests

trial in Ischemic Stroke in 32 participants. Completed in 31 January 2023.

Timeline
2 January 2022
Primary endpoint
31 January 2023
31 January 2023

Quick facts

Lead sponsorMedical University of Lodz
StatusCompleted
Study typeOBSERVATIONAL
Enrollment32
Start date2 January 2022
Primary completion31 January 2023
Estimated completion31 January 2023
Sites1 location across Poland

Conditions studied

Sponsor

Medical University of Lodz

Who can join

18 and older, any sex, with Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Despite increasingly effective early treatment strategies for ischemic stroke, post-stroke recovery is often incomplete and depend on spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. These processes are regulated by growth factors, neurotrophines, neurotransmitters, hormones and other factors. This study aims to search biomarkers that prognose brain repair ability and consequently estimate an outcome of stroke patients. The prognostic value of proteins VEGF, IGF-1 and MMP-9 and expression of genes VEGF, IGF-1, MMP-9 is evaluated in association with clinical scales including cognitive assessment scales and depression scales. Blood sample collection as well as scales recording are taken at baseline and 3 weeks later after rehabilitation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation-A Prospective Observational Study.
    Włodarczyk L, Cichoń N, Karbownik MS, Saso L, et al · · 2023 · cited 11× · PMID 37371326 · DOI 10.3390/brainsci13060846
  2. Exploring the Role of MMP-9 and MMP-9/TIMP-1 Ratio in Subacute Stroke Recovery: A Prospective Observational Study.
    Włodarczyk L, Cichon N, Karbownik MS, Saluk J, et al · · 2024 · cited 2× · PMID 38891934 · DOI 10.3390/ijms25115745

Verify or expand the search:

Other recruiting trials for Ischemic Stroke

Currently open trials in the same condition.

Other Medical University of Lodz trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05750303.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing