NCT05746767 (SUPERA) is a NA clinical trial of Supported dCBT in Depression, Anxiety, sponsored by University of California, Irvine.

Who is sponsoring NCT05746767?

NCT05746767 is sponsored by University of California, Irvine.

What drugs are being tested in NCT05746767?

Interventions in NCT05746767: Supported dCBT, Unsupported dCBT.

What condition does NCT05746767 study?

NCT05746767 studies Depression, Anxiety.

Is NCT05746767 still recruiting?

NCT05746767 is currently enrolling by invitation. Last updated 23 January 2026.

Last reviewed 2026-01-23 · How we verify

NCT05746767: SUPERA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Supporting Peer Interactions to Expand Access to Digital Cognitive Behavioral Therapy for Spanish-speaking Patients

ENROLLING BY INVITATION NA Last updated 23 January 2026

What this trial tests

NA trial testing Supported dCBT in Depression, Anxiety in 426 participants. Enrolling by invitation.

Timeline

14 March 2024

Primary endpoint
1 March 2027

1 March 2027

Quick facts

Lead sponsor	University of California, Irvine
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	426
Start date	14 March 2024
Primary completion	1 March 2027
Estimated completion	1 March 2027
Sites	11 locations across United States

Drugs / interventions tested

Supported dCBT
Unsupported dCBT

Conditions studied

Depression, Anxiety — all drugs for Depression, Anxiety →

Sponsor

University of California, Irvine

Who can join

18 and older, any sex, with Depression, Anxiety. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy intervention (SilverCloud) in primary care settings for Latino patients with depression and/or anxiety. 426 participants will be enrolled in a two-armed trial comparing self-guided vs. supported dCBT (SilverCloud). At the provider level, investigators will compare the efficacy of provider referrals with the use of a clinic patient registry to identify candidates who could benefit from a digital mental health intervention.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effectiveness-implementation hybrid trial of Spanish language, digital cognitive-behavioral therapy (dCBT) intervention for depression and anxiety - protocol for the SUPERA (SUpport from PEeRs to expand Access) study.
Aguilera A, Arévalo Avalos MR, Rosales K, Reyes Y, et al · · 2024 · cited 3× · PMID 38145715 · DOI 10.1016/j.cct.2023.107422

Verify or expand the search:

Other recruiting trials for Depression, Anxiety

Currently open trials in the same condition.

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NCT07186816 — SUpport From PEeRs to Expand Access Study - Community · NA · recruiting
NCT07091032 — Building Connections · NA · recruiting

Other University of California, Irvine trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05746767 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Irvine
Last refreshed: 23 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05746767.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing