Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes

NCT05743868 NA RECRUITING

The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis in these groups.

Details

Lead sponsor	Yale University
Phase	NA
Status	RECRUITING
Enrolment	40
Start date	2023-11-16
Completion	2026-06

Conditions

• Insulin Resistance
• Hypertriglyceridemia

Interventions

• Standardized Dinner
• Premeal exercise

Primary outcomes

• Effect of tissue-specific insulin resistance on contribution of DNL to plasma triglyceride — Baseline
  The amount of de novo lipogenesis (DNL) in VLDL-triglycerides after a standard meal will be measured in plasma from whole blood. Relationship between DNL and 1) whole body (skeletal muscle) insulin resistance and 2) white adipose tissue insulin resistance will be assessed individually.
• Change in DNL in VLDL-triglycerides after a standard meal compared to a standard meal with premeal exercise. — study visit 1 and study visit 2, up to 8 weeks
  The amount of de novo lipogenesis (DNL) in VLDL-triglycerides after a standard meal vs after a standard meal with premeal exercise will be measured in plasma from whole blood.

Countries

Netherlands