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NCT05742399
Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
Phase 1, PHASE2 trial testing Hyaluronic acid NanoGel in Tear Trough Eyelid Deformity in 30 participants. Completed in 15 January 2024.
15 September 2023
Quick facts
| Lead sponsor | Alexandria University |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 21 December 2022 |
| Primary completion | 15 September 2023 |
| Estimated completion | 15 January 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Hyaluronic acid NanoGel — full drug profile →
- Placebo gel
Conditions studied
- Tear Trough Eyelid Deformity — all drugs for Tear Trough Eyelid Deformity →
- Dark Eyelids — all drugs for Dark Eyelids →
- Wrinkle — all drugs for Wrinkle →
Sponsor
Alexandria University
Who can join
Adults 21 to 65, any sex, with Tear Trough Eyelid Deformity or Dark Eyelids. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, The investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler injections.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Progress in Topical and Transdermal Drug Delivery Research-Focus on Nanoformulations.
Lunter D, Klang V, Eichner A, Savic SM, et al · · 2024 · cited 22× · PMID 38931938 · DOI 10.3390/pharmaceutics16060817 -
Inflammation-modulating polymeric nanoparticles: design strategies, mechanisms, and therapeutic applications.
Zhang H, Chen H, Hu X, Muhammad W, et al · · 2025 · cited 8× · PMID 40614330 · DOI 10.1016/j.ebiom.2025.105837 -
Bioresponsive engineered nanoparticles for immunomodulation.
Hegde M, Mishra A, Banerjee R, Bintee B, et al · · 2025 · cited 4× · PMID 41162977 · DOI 10.1186/s12916-025-04305-6
Verify or expand the search:
- PubMed search for NCT05742399
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05742399 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alexandria University
- Last refreshed: 31 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05742399.
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