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NCT05741970
Interaction Between Hypertension and Periodontitis
NA trial testing Scaling and root planing in Hypertension in 42 participants. Completed in 25 June 2018.
30 March 2018
Quick facts
| Lead sponsor | Gazi University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 42 |
| Start date | 2 January 2017 |
| Primary completion | 30 March 2018 |
| Estimated completion | 25 June 2018 |
Drugs / interventions tested
- Scaling and root planing
Conditions studied
- Hypertension — all drugs for Hypertension →
- Periodontitis — all drugs for Periodontitis →
Sponsor
Gazi University
Who can join
Adults 39 to 58, any sex, with Hypertension or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objective:The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)-6 and C reactive protein (CRP) levels. Methods:Forty two healthy individuals without any previously diagnosed systemic disease \[10 periodontally healthy (control) and 10 periodontitis (CP)\] and subjects with hypertension \[13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)\] participated in the study. GCF and saliva samples were obtained at baseline and four weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA. Results:Before the periodontal treatment, significantly higher GCF IL-6 and CRP levels were detected in CP+HP and CP groups compared to HP and control groups (p\<0.01). Salivary CRP level in CP+HP group was found to be higher than the control group (p\<0.05). Statistically significant gingival and plaque index measurements (p\<0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices, however biochemical parameters did not change after the treatment. Conclusion:the association of hypertension with periodontitis through local salivary and GCF mediators might be possible in disease process.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05741970
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Trials testing the same drug.
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Currently open trials in the same condition.
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Other Gazi University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05741970 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gazi University
- Last refreshed: 23 February 2023
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