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NCT05733234
Lasers in Peri-implantitis Treatment
NA trial testing Laser ,Fotona, Light Walker AT, Ljubljana, Slovenia in Peri-Implantitis in 20 participants. Completed in 21 March 2022.
21 March 2022
Quick facts
| Lead sponsor | Aristotle University Of Thessaloniki |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 20 May 2021 |
| Primary completion | 21 March 2022 |
| Estimated completion | 21 March 2022 |
| Sites | 1 location across Greece |
Drugs / interventions tested
- Laser ,Fotona, Light Walker AT, Ljubljana, Slovenia
- Mechanical Treatment — full drug profile →
Conditions studied
- Peri-Implantitis — all drugs for Peri-Implantitis →
Sponsor
Aristotle University Of Thessaloniki
Who can join
Eligibility, male only, with Peri-Implantitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The current study aimed to investigate the effect of the combined Nd-Er: YAG laser on the surgical treatment of peri-implantitis by evaluating clinical markers and biomarkers of bone loss (RANKL/OPG). Twenty (20) patients having at least 1 implant diagnosed with peri-implantitis were randomly assigned to two groups for surgical treatment. In the test group (n=10), Er: YAG laser was used for granulation tissue removal and implant surface decontamination, while Nd: YAG laser was employed for deep tissue decontamination and biomodulation. In the control group (n=10), an access flap was applied, and mechanical instrumentation of the implant surface was performed by using titanium curettes. The following clinical parameters were evaluated at baseline and six months after treatment: Full-mouth Plaque Score (FMPS), Probing Pocket Depth (PPD), Probing Attachment Levels (PAL), recession (REC), and Bleeding on probing (BoP). Peri-implant crevicular fluid (PICF) was collected at baseline and six months for the evaluation of soluble RANKL and OPG utilizing enzyme-linked immunosorbent assay (ELISA).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Surgical Treatment of Peri-Implantitis Using a Combined Nd: YAG and Er: YAG Laser Approach: Investigation of Clinical and Bone Loss Biomarkers.
Fragkioudakis I, Kallis A, Kesidou E, Damianidou O, et al · · 2023 · cited 10× · PMID 36975558 · DOI 10.3390/dj11030061
Verify or expand the search:
- PubMed search for NCT05733234
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Peri-Implantitis
Currently open trials in the same condition.
- NCT07012915 — Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis · NA · recruiting
- NCT06679283 — Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · NA · recruiting
- NCT06017817 — Antibacterial Photodynamic Therapy in the Management of Peri-implantitis · NA · recruiting
- NCT06364982 — Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. · recruiting
- NCT06288919 — Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials · NA · active not recruiting
Other Aristotle University Of Thessaloniki trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05733234 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aristotle University Of Thessaloniki
- Last refreshed: 17 February 2023
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