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NCT05732974: MIRACLE

A Machine Learning Approach to Identify Patients With Resected Non-small-cell Lung Cancer With High Risk of Relapse

Recruiting now Last updated 21 September 2023
What this trial tests

trial testing Resected non small cell lung cancer in Non-small Cell Lung Cancer Stage IIIA in 60 participants. Currently enrolling.

Timeline
30 March 2023
Primary endpoint
30 November 2025
30 October 2026

Quick facts

Lead sponsorUniversity Hospital, Toulouse
StatusRecruiting now
Study typeOBSERVATIONAL
Enrollment60
Start date30 March 2023
Primary completion30 November 2025
Estimated completion30 October 2026
Sites1 location across France

Drugs / interventions tested

Conditions studied

Sponsor

University Hospital, Toulouse

Who can join

18 and older, any sex, with Non-small Cell Lung Cancer Stage IIIA. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Early-stage non small cell lung cancer represents 20-30% of all non small cell lung cancer and is characterized by a high survival probability after surgical resection. However, considering stage IA-IIIA non small cell lung cancer, a relapse rate of about 50% is observed, with a different survival probability on the basis of tumor node metastasis status, although patients within the same tumor node metastasis stage exhibit wide variations in recurrence rate. There are currently no validated prognostic biomarkers able to identify patients with a high risk of relapse.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.
    Chatterjee M, Nag S, Gupta S, Mukherjee T, et al · · 2025 · cited 8× · PMID 40067551 · DOI 10.1007/s12672-025-02054-9
  2. Exploring the clinical utility of liquid biopsy with cfDNA in cancer: A systematic review.
    Ranganathan K, Kurian NS, Goswami HM, Rishi KD, et al · · 2024 · cited 5× · PMID 40027943 · DOI 10.1016/j.jlb.2024.100150

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Other University Hospital, Toulouse trials

Trials by the same sponsor.

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Data sources for this page

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