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NCT05732883
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Phase 2 trial testing Dexamethasone in Voice Change in 100 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Tseung Kwan O Hospital, Hong Kong |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 1 July 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 September 2026 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Dexamethasone (dexamethasone) — full drug profile →
- Normal saline
Conditions studied
- Voice Change — all drugs for Voice Change →
- Hypocalcemia — all drugs for Hypocalcemia →
Sponsor
Tseung Kwan O Hospital, Hong Kong
Who can join
18 and older, any sex, with Voice Change or Hypocalcemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong. Total thyroidectomy is associated with voice dysfunction and temporary hypocalcaemia in up to 80% and 50%, respectively. Previous study from our institute showed a 3% rate of permanent vocal cord palsy and 16% of permanent hypoparathyroidism requiring calcium and/or vitamin D supplements. The use of dexamethasone has been studied in the past in total thyroidectomy patients and has been shown to be safe and effective in improving post-operative nausea and vomiting. No complications or drug related side effects were associated with a single dose of steroid. Recent studies have also shown that Dexamethasone is effective in improving voice outcome and hypocalcaemia in thyroidectomy patients. The investigators aim to study the effect of Dexamethasone in post-operative voice outcome and hypocalcaemia. Objective assessment of the vocal cords during phonation will be performed pre-operative and post-operatively. Serum Calcium level will be monitored.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05732883
- Europe PMC full search
- ASCO Meeting Library
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Related trials
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Trials testing the same drug.
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Other recruiting trials for Voice Change
Currently open trials in the same condition.
- NCT07008859 — Correlation Between Voice Pitch Changes and Tension of Suboccipital Muscles In Normal Subjects · active not recruiting
- NCT06002984 — Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve in Thyroid Surgery · NA · recruiting
Other Tseung Kwan O Hospital, Hong Kong trials
Trials by the same sponsor.
- NCT07376668 — Effects of a WhatsApp-assisted Prehabilitation for Patient Undergoing Elective Colorectal Cancer Surgery · NA · not yet recruiting
- NCT06225765 — A Prospective Trial Comparing Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) and Conventional Open Thyr · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05732883 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tseung Kwan O Hospital, Hong Kong
- Last refreshed: 9 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05732883.
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