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NCT05732818: LOPAIN3
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy 3
NA trial testing PerQdisc Nucleus Replacement System in Back Pain With Radiation in 50 participants. Suspended.
16 September 2026
Quick facts
| Lead sponsor | Spinal Stabilization Technologies |
|---|---|
| Phase | NA |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 16 June 2023 |
| Primary completion | 16 September 2026 |
| Estimated completion | 16 June 2027 |
| Sites | 2 locations across Paraguay, Uzbekistan |
Drugs / interventions tested
- PerQdisc Nucleus Replacement System
Conditions studied
- Back Pain With Radiation — all drugs for Back Pain With Radiation →
- Radiculopathy — all drugs for Radiculopathy →
- Back Pain — all drugs for Back Pain →
- Disc Herniation — all drugs for Disc Herniation →
Sponsor
Spinal Stabilization Technologies — full company profile →
Who can join
21 and older, any sex, with Back Pain With Radiation or Radiculopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is a First in Human, prospective, multi-center clinical study intended to collect safety and performance information for the Spinal Stabilization Technologies PerQdisc® Nucleus Replacement System and procedure concurrently following a successful discectomy using a minimally invasive posterolateral (MIPL) approach. Patients that are at least 21 years or older, presenting with symptomatic radiculopathy from a focal lumbar disc herniation that requires surgical decompression will be included in this study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Bioactive Therapies for Degenerative Disc Disease: Current State of the Art and Clinical Applications.
Ikwuegbuenyi CA, Fidai AB, Cardenas A, Willett N, et al · · 2025 · cited 7× · PMID 40409593 · DOI 10.1016/j.wneu.2025.124107
Verify or expand the search:
- PubMed search for NCT05732818
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of PerQdisc Nucleus Replacement System
Trials testing the same drug.
- NCT05508360 — "Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2) · NA · recruiting
Other Spinal Stabilization Technologies trials
Trials by the same sponsor.
- NCT06860867 — PerQdisc Traditional Feasibility Trial. · NA · recruiting
- NCT05508360 — "Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2) · NA · recruiting
- NCT05105490 — Post Market Observational Trial for the PerQdisc Nucleus Replacement Device · withdrawn
- NCT04141098 — Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy · NA · terminated
- NCT04004156 — Safety Study for An Artificial Disc Nucleus Replacement to Treat Chronic Low Back Pain · NA · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05732818 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Spinal Stabilization Technologies
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05732818.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing