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NCT05731882
First in Man Study of Left Atrial Appendage Pulsed Field Ablation Occluder
NA trial testing E-SeaLA, CardioPulse PFA system in Nonvalvular Atrial Fibrillation in 10 participants. Status unknown.
1 June 2024
Quick facts
| Lead sponsor | Hangzhou Dinova EP Technology Co., Ltd |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 17 July 2022 |
| Primary completion | 1 June 2024 |
| Estimated completion | 1 August 2024 |
| Sites | 3 locations across China |
Drugs / interventions tested
- E-SeaLA, CardioPulse PFA system
Conditions studied
- Nonvalvular Atrial Fibrillation — all drugs for Nonvalvular Atrial Fibrillation →
Sponsor
Hangzhou Dinova EP Technology Co., Ltd — full company profile →
Who can join
Adults 18 to 80, any sex, with Nonvalvular Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is the first in man study of E-SeaLATM developed and manufactured by Hangzhou Dinova EP Technology Co., Ltd, which can achieve pulsed field ablation and mechanical closure of the Left Atrial Appendage simultaneously, this study aims to initially verify the safety and efficacy of the device.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Simultaneous Pulsed Field Ablation and Mechanical Closure of Left Atrial Appendage Using a Novel Device.
Tang M, Wang X, Reddy VY. · · 2023 · cited 3× · PMID 37790777 · DOI 10.1016/j.jaccas.2023.101963 -
Combined Catheter Ablation and Left Atrial Appendage Occlusion in Atrial Fibrillation: From Data to Clinical Reality.
Dimitriadis K, Adamopoulou E, Pyrpyris N, Iliakis P, et al · · 2026 · cited 1× · PMID 40237856 · DOI 10.1007/s10557-025-07685-2
Verify or expand the search:
- PubMed search for NCT05731882
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Nonvalvular Atrial Fibrillation
Currently open trials in the same condition.
- NCT07125417 — Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure · Phase 4 · recruiting
Other Hangzhou Dinova EP Technology Co., Ltd trials
Trials by the same sponsor.
- NCT07036965 — Comparison of Different Pulsed Field Ablation Catheters in Atrial Fibrillation · NA · recruiting
- NCT06157437 — An Exploratory Study of Focal Pulse Ablation System in the Treatment of Atrial Arrhythmia · NA · recruiting
- NCT05360771 — Study on the Safety and Effectiveness of the SnowyTM PFO Closure System · NA · not yet recruiting
- NCT05114954 — Evaluation of the Safety and Efficacy of the CardioPulseTM PuLsed fiEld Ablation SystEm in Patients With Paroxysmal Atri · NA · completed
- NCT07452211 — First in Man Study of Pulsed Field Ablation System for the Treatment of Paroxysmal Atrial Fibrillation in 1 Patient · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05731882 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hangzhou Dinova EP Technology Co., Ltd
- Last refreshed: 17 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05731882.
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