NCT05731349 (NEWS-1-TRIPS) is a NA clinical trial of 2018 Surviving Sepsis Campaign Hour-1 Bundle in Sepsis, sponsored by The University of Hong Kong.

Who is sponsoring NCT05731349?

NCT05731349 is sponsored by The University of Hong Kong.

What drugs are being tested in NCT05731349?

Interventions in NCT05731349: 2018 Surviving Sepsis Campaign Hour-1 Bundle.

What condition does NCT05731349 study?

NCT05731349 studies Sepsis, Septic Shock.

Is NCT05731349 still recruiting?

NCT05731349 is currently completed. Last updated 22 July 2024.

Last reviewed 2024-07-22 · How we verify

NCT05731349: NEWS-1-TRIPS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department

Completed NA Last updated 22 July 2024

What this trial tests

NA trial testing 2018 Surviving Sepsis Campaign Hour-1 Bundle in Sepsis in 200 participants. Completed in 31 May 2024.

Timeline

1 April 2023

Primary endpoint
31 May 2024

31 May 2024

Quick facts

Lead sponsor	The University of Hong Kong
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	200
Start date	1 April 2023
Primary completion	31 May 2024
Estimated completion	31 May 2024
Sites	4 locations across Hong Kong

Drugs / interventions tested

2018 Surviving Sepsis Campaign Hour-1 Bundle

Conditions studied

Sepsis — all drugs for Sepsis →
Septic Shock — all drugs for Septic Shock →

Sponsor

The University of Hong Kong

Who can join

18 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this pilot clinical trial is to determine the feasibility of conducting a fully powered type 1 hybrid effectiveness-implementation trial on early sepsis care that is guided by early warning score in adult emergency department (ED) patients who have infection. The main questions it aims to answer are: * Is it feasible to execute the trial procedure and fulfill the progression criteria to a full-scale trial? * Does the Surviving Sepsis Campaign (SSC) Hour-1 Bundle care reduce the mortality of adult ED patients with a clinical diagnosis of infection and a National Early Warning Score 2 (NEWS2) equal to or greater than 5? * What are the barriers to and facilitators of the implementation of the SSC Hour-1 Bundle in the ED settings? Participants will receive the following SSC Hour-1 Bundle care during the intervention period: * Blood lactate level measurement * Blood cultures collection before administering antibiotics * Broad-spectrum antibiotics * Intravenous fluid * Vasopressors if the blood pressure remains low during or after fluid replacement to maintain the mean arterial blood pressure equal to or greater than 65 mmHg Researchers will compare patients who receive SSC Hour-1 Bundle triggered by a NEWS2 equal to or greater than 5 and patients who receive standard treatment based on clinical judgement to see if the SSC Hour-1 that is triggered by a high NEWS2 score could reduce mortality of adult ED patients with infection.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Early sepsis care with the National Early Warning Score 2-guided Sepsis Hour-1 Bundle in the emergency department: hybrid type 1 effectiveness-implementation pilot stepped wedge randomised controlled trial (NEWS-1 TRIPS) protocol.
Lam RPK, Hung KKC, Lui CT, Kwok WS, et al · · 2024 · cited 3× · PMID 38307529 · DOI 10.1136/bmjopen-2023-080676

Verify or expand the search:

Other recruiting trials for Sepsis

Currently open trials in the same condition.

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NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
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Other The University of Hong Kong trials

Trials by the same sponsor.

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NCT07448649 — Chatbot-Assisted Advance Care Planning Education for Family Members · NA · not yet recruiting
NCT07484932 — TRTRM (ACTTOP) -Guided Dosing Strategy in Older Patients With Cancer · NA · not yet recruiting
NCT07531589 — BrainLive Connect: Non-professional Delivered CST for People Living With Dementia · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05731349 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Hong Kong
Last refreshed: 22 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05731349.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing