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NCT05724654
Effects of Peanut Consumption on Brain Function
NA trial testing Skin roasted peanuts in Brain Vascular Function in 31 participants. Completed in 11 July 2024.
11 July 2024
Quick facts
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 31 |
| Start date | 2 February 2023 |
| Primary completion | 11 July 2024 |
| Estimated completion | 11 July 2024 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Skin roasted peanuts
Conditions studied
- Brain Vascular Function — all drugs for Brain Vascular Function →
- Cerebral Blood Flow — all drugs for Cerebral Blood Flow →
- Brain Insulin Sensitivity — all drugs for Brain Insulin Sensitivity →
- Cognitive Performance — all drugs for Cognitive Performance →
Sponsor
Maastricht University Medical Center
Who can join
Adults 60 to 75, any sex, with Brain Vascular Function or Cerebral Blood Flow. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline. Peanut consumption has already been shown to beneficially affect cognitive performance. However, underlying mechanisms have not yet been established, while well-controlled trials on longer-term effects of peanuts on cognitive performance are highly needed. The hypothesis is that longer-term peanut consumption has beneficial effects on (regional) cerebral blood flow responses (primary outcome), which may relate to an improved cognitive performance (secondary outcome) in older men and women. Important objectives are to investigate in older adults the effect of 16-week peanut consumption on (i) brain vascular function in cognitive-control brain areas, and (ii) brain insulin-sensitivity. We will also focus on changes in cognitive performance as assessed with a neuropsychological test battery (secondary objective). Cerebral blood flow responses before (brain vascular function) and after the administration of intranasal insulin (brain insulin-sensitivity) will be quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-perfusion method Arterial Spin Labeling (ASL).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Longer-term skin-roasted peanut consumption improves brain vascular function and memory: A randomized, single-blind, controlled crossover trial in healthy older adults.
Kerkhof L, Mensink RP, Plat J, Nijssen KMR, et al · · 2025 · PMID 41205298 · DOI 10.1016/j.clnu.2025.10.020
Verify or expand the search:
- PubMed search for NCT05724654
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other recruiting trials for Brain Vascular Function
Currently open trials in the same condition.
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Other Maastricht University Medical Center trials
Trials by the same sponsor.
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- NCT04598516 — Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30 · withdrawn
- NCT04597892 — Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast · withdrawn
- NCT07287358 — Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II · NA · not yet recruiting
- NCT07501780 — Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05724654 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maastricht University Medical Center
- Last refreshed: 29 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05724654.
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