NCT05723939

Carnosine Supplementation and Cardiovascular Function

Status unknown NA Last updated 14 February 2023

What this trial tests

NA trial testing Carnosine supplementation in Carnosine in 100 participants. Status unknown.

Timeline

1 September 2022

Primary endpoint
31 December 2023

30 June 2024

Quick facts

Lead sponsor	Josip Juraj Strossmayer University of Osijek
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	100
Start date	1 September 2022
Primary completion	31 December 2023
Estimated completion	30 June 2024
Sites	1 location across Croatia

Drugs / interventions tested

• Carnosine supplementation
• Controls

Conditions studied

• Carnosine — all drugs for Carnosine →

Sponsor

Josip Juraj Strossmayer University of Osijek

Who can join

Adults 18 to 39, any sex, with Carnosine. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high concentrations in the brain, heart, and gastrointestinal tissues of humans. Although its physiological role has not been completely understood yet, carnosine is a non-enzymatic free-radical scavenger and a natural antioxidant and has anti-inflammatory and neuroprotective properties.

The hypothesis of this research is that the consumption of carnosine supplements in the form of capsules, as well as chicken meat enriched with carnosine (functional food) has a beneficial effect on vascular reactivity measured in different vascular basins, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary people. subjects and active athletes measured in different vascular basins.

The main goal of this study is to investigate the influence of carnosine supplement consumption (in the form of capsules and functional food) on vascular and endothelial function in a population of healthy young subjects and active athletes.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study.
   Perić L, Drenjančević I, Jukić I, Boris A, et al · · 2025 · cited 1× · PMID 39983097 · DOI 10.1139/apnm-2024-0458
2. Carnosine-Enriched Chicken Meat Improves Microvascular Function and Anti-Inflammatory Phenotype in Patients with Chronic Coronary Syndrome.
   Uršić D, Kolobarić N, Drenjančević I, Mihaljević Z, et al · · 2026 · PMID 41901102 · DOI 10.3390/nu18060928
3. Antioxidant Effects of Carnosine-Enriched Chicken Meat Consumption in Athletes: Modulation of SOD Activity and Superoxide Levels-A Randomized Control Trial.
   Kolobarić N, Perić L, Mihaljević Z, Šušnjara P, et al · · 2025 · PMID 41008974 · DOI 10.3390/antiox14091069
4. Assessment of Micro- and Macronutrient Intake in Male Competitive Athletes Using the Epic-Norfolk Food Frequency Questionnaire.
   Stupin A, Perić L, Jukić I, Boris A, et al · · 2025 · PMID 40141802 · DOI 10.3390/life15030458