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NCT05723731
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation
NA trial testing taVNS in Chronic Constipation in 106 participants. Terminated before completion.
31 July 2023
Quick facts
| Lead sponsor | Air Force Military Medical University, China |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 106 |
| Start date | 3 January 2023 |
| Primary completion | 31 July 2023 |
| Estimated completion | 28 September 2023 |
| Sites | 5 locations across China |
Drugs / interventions tested
- taVNS
- Laxative Agent — full drug profile →
Conditions studied
- Chronic Constipation — all drugs for Chronic Constipation →
Sponsor
Air Force Military Medical University, China
Who can join
Adults 18 to 75, any sex, with Chronic Constipation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance. The conventional medication treatments are primarily symptom-specific and have limited efficacy. Previous small sample study had shown the therapeutic potential of transcutaneous auricular vagus nerve stimulation (taVNS) for irritable bowel syndrome with constipation (IBS-C). The aim of this study was to investigate whether taVNS could improve defecation condition and constipation symptoms in patients with CC.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation: A Multicenter, Randomized Controlled Study.
Liu T, Wang Z, Li Y, Kang X, et al · · 2025 · cited 2× · PMID 40359320 · DOI 10.1002/ueg2.70041
Verify or expand the search:
- PubMed search for NCT05723731
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of taVNS
Trials testing the same drug.
- NCT07272954 — Effects of Ultrasound-Guided Stellate Ganglion Block and Transcutaneous Auricular Vagus Nerve Stimulation on Sleep Quali · NA · not yet recruiting
- NCT07517237 — taVNS + CCT for Neurocognitive Rehab · NA · recruiting
- NCT07049952 — BabySTrong II taVNS Feeding Trial · Phase 2, PHASE3 · recruiting
- NCT07063446 — sTMS Combined With CIMT and taVNS In Infants With Hemiplegia · NA · recruiting
- NCT06998784 — Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Acute Pancreatitis · NA · completed
Other recruiting trials for Chronic Constipation
Currently open trials in the same condition.
- NCT07387952 — The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of F · NA · recruiting
- NCT06911749 — MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders · NA · recruiting
- NCT06847919 — Exploring the Potential Benefits of Probiotic Yogurt · NA · recruiting
- NCT06543979 — Anorectal Manometery in Pediatric Chronic Refractory Constipation · Phase 1, PHASE2 · recruiting
- NCT03819062 — Sacral Neuromodulation as Treatment for Chronic Constipation · NA · recruiting
Other Air Force Military Medical University, China trials
Trials by the same sponsor.
- NCT07535138 — Efficacy and Safety of CD19 CAR-γδ T Cells in the Treatment of Relapsed/Refractory Autoimmune Nephropathy · EARLY_PHASE1 · not yet recruiting
- NCT07454408 — Evaluation of the Outcome of Fecal Microbiota Transplantation · Phase 1, PHASE2 · not yet recruiting
- NCT07329660 — Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients · NA · not yet recruiting
- NCT07365345 — Frequency of Electrical Acupoint Stimulation on Hypotension in TAVR Patients · NA · recruiting
- NCT07338448 — Electrical Acupoint Stimulation on Gastric Reflux During I-gel Ventilation · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05723731 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Air Force Military Medical University, China
- Last refreshed: 10 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05723731.
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