NCT05723523: CI Wizard

A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment

Completed NA Last updated 4 November 2025

What this trial tests

NA trial testing CI-CDS in Dementia in 3,230 participants. Completed in 30 September 2025.

Timeline

23 August 2023

Primary endpoint
31 August 2025

30 September 2025

Quick facts

Lead sponsor	HealthPartners Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	3,230
Start date	23 August 2023
Primary completion	31 August 2025
Estimated completion	30 September 2025
Sites	2 locations across United States

Drugs / interventions tested

• CI-CDS

Conditions studied

• Dementia — all drugs for Dementia →
• Cognitive Impairment — all drugs for Cognitive Impairment →

Sponsor

HealthPartners Institute

Who can join

65 and older, any sex, with Dementia or Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Most experts advocate for early detection of cognitive impairment (CI) so that patients and caregivers can be prepared for making difficult decisions and to improve quality of life, but studies show that screening alone isn't sufficient to change clinician actions related to early detection. Using predictive modelling developed with machine learning methods and sophisticated clinical decision support (CDS) tools, it is possible to identify patients at elevated risk for CI and make it much easier for primary care to engage and support patients and caregivers in meaningful care planning. The goal of this study is to implement and evaluate a low-cost, highly scalable CI-CDS system integrated within the electronic health record that has high potential to improve early CI detection and care and translate massive public and private sector investments in health informatics into tangible health benefits for large numbers of people.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Confidence in diagnosing and managing care for cognitive impairment in primary care: a survey comparing barriers by primary care clinician type.
   JaKa MM, Rossom RC, Borson S, O'Connor PJ, et al · · 2024 · cited 6× · PMID 39221923 · DOI 10.1093/fampra/cmae043
2. Exposure to clinical decision support and training increases primary care clinician confidence in managing cognitive impairment care but not confidence to diagnose.
   JaKa MM, Rossom RC, Crouse B, Crain AL, et al · · 2025 · PMID 41225324 · DOI 10.1186/s12875-025-03053-z
3. Design and protocol of a pragmatic clinical trial to improve cognitive impairment detection in primary care.
   Crouse B, Rossom RC, Crain AL, O'Connor PJ, et al · · 2025 · PMID 40953636 · DOI 10.1016/j.cct.2025.108080