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Prospective Study of Stereotactic Radiosurgery Using Diffusion-Weighted Abnormality Versus Chemotherapy for Recurrent/Progressive Glioblastoma After Second-line Chemotherapy
This clinical trial is a prospective study of radiosurgery treatment for progressive GBM to test 1)the efficacy of radiosurgery for recurrent/progressive GBM compared to chemotherapy , and 2) the role of diffusion-weighted image (DWI) to predict the early tumor progression and treatment response.
Details
| Lead sponsor | Henry Ford Health System |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 35 |
| Start date | 2010-11 |
| Completion | 2016-12 |
Conditions
- Recurrent or Progressive Glioblastoma
Interventions
- Bevacizumab
- Chemotherapy
- Fractionated radiosurgery
Primary outcomes
- Local Tumor Control — 2 months
- Overall Survival — 12 months
- Progression Free Survival — 12 months
Countries
United States