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NCT05718271
Effects of Verbal Instructions on Fear Extinction and Extinction Retrieval
NA trial testing Explicit instructions before extinction in Anxiety Disorder in 240 participants. Completed in 14 August 2024.
14 August 2024
Quick facts
| Lead sponsor | Ruhr University of Bochum |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 240 |
| Start date | 2 February 2023 |
| Primary completion | 14 August 2024 |
| Estimated completion | 14 August 2024 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Explicit instructions before extinction
- Explicit instructions after extinction
Conditions studied
- Anxiety Disorder — all drugs for Anxiety Disorder →
Sponsor
Ruhr University of Bochum
Who can join
Adults 18 to 60, any sex, with Anxiety Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to examine if verbal instructions can improve fear extinction learning and extinction retrieval in patients with anxiety disorders (AD) and healthy controls.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Timing matters: Providing Contingency Instructions to modify Fear Extinction Memories in Anxiety Disorders
Lipp A, Merz CJ, Macit B, Woud ML, et al · · 2026 · DOI 10.31234/osf.io/kma2e_v4
Verify or expand the search:
- PubMed search for NCT05718271
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Ruhr University of Bochum trials
Trials by the same sponsor.
- NCT07432945 — In Vivo Exposure vs. Videochat-Based Vicarious Exposure · NA · recruiting
- NCT06255821 — The Effect of Time on Generalization of Exposure-based Benefit · NA · completed
- NCT05824884 — Self-efficacy Enhancement in a Virtual Reality Training for Fear of Heights · NA · recruiting
- NCT05798078 — The Relationship Between Social Anxiety and Anxious Thinking Styles · NA · completed
- NCT05780203 — CBM in the Context of Exposure for Acrophobia · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05718271 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ruhr University of Bochum
- Last refreshed: 20 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05718271.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing