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NCT05716620

Utility of Abbreviated Magnetic Resonance Imaging as a Screening Tool for Hepatocellular Carcinoma in Cirrhotic Patients

Status unknown Last updated 8 February 2023
What this trial tests

trial testing MRI in Hepatocellular Carcinoma in 380 participants. Status unknown.

Timeline
8 February 2022
Primary endpoint
7 February 2025
7 February 2025

Quick facts

Lead sponsorPost Graduate Institute of Medical Education and Research, Chandigarh
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment380
Start date8 February 2022
Primary completion7 February 2025
Estimated completion7 February 2025
Sites1 location across India

Drugs / interventions tested

Conditions studied

Sponsor

Post Graduate Institute of Medical Education and Research, Chandigarh

Who can join

Adults 40 to 65, any sex, with Hepatocellular Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is Utility of abbrevational magnetic resonance imaging as a screening tool for hepatocellular carcinoma in cirrhotic patients. The primary objective of the study is: • HCC detection rate of US vs AMRI in cirrhotic patients The secondary objective of the study are: * False referral rate of US vs AMRI: false referral will be defined as lack of HCC on complete MRI despite a positive US or AMRI. * Positive predictive value of US vs AMRI: The positive predictive value will be defined as the number of patients with true positive results in patients with positive US/AMRI. Participants will be evaluated by two rounds of screening 6 months apart using paired US and non-enhanced AMRI.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Recent advances and issues in imaging modalities for hepatocellular carcinoma surveillance.
    Lee DH. · · 2025 · cited 5× · PMID 40007309 · DOI 10.17998/jlc.2025.02.16
  2. Persisting challenges in the early detection of hepatocellular carcinoma.
    Arvind A, Redmon K, Singal AG. · · 2025 · cited 3× · PMID 39943795 · DOI 10.1080/14737140.2025.2467184
  3. Abbreviated MRI-Based Surveillance Strategies for Early Hepatocellular Carcinoma Detection.
    Park HJ, Kim DW, Choi WM, Kim SY. · · 2025 · cited 1× · PMID 40502477 · DOI 10.3348/jksr.2024.0153
  4. Noncontrast abbreviated MRI demonstrates superior diagnostic accuracy compared to ultrasound for hepatocellular carcinoma detection: Interim results from a prospective surveillance trial.
    Gupta P, Singh S, Gulati A, Mudgil P, et al · · 2026 · PMID 42113186 · DOI 10.1097/hep.0000000000001788
  5. How to Design a Study and Write a Grant in Radiology?
    Gupta P, Singhal M. · · 2025 · PMID 39802716 · DOI 10.1055/s-0044-1792077

Verify or expand the search:

Other trials of MRI

Trials testing the same drug.

Other recruiting trials for Hepatocellular Carcinoma

Currently open trials in the same condition.

Other Post Graduate Institute of Medical Education and Research, Chandigarh trials

Trials by the same sponsor.

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Data sources for this page

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing