Who is sponsoring NCT05715866?

NCT05715866 is sponsored by Universidad de Murcia.

What drugs are being tested in NCT05715866?

Interventions in NCT05715866: non-invasive neuromodulation through the Nesa device, therapeutic exercise, sleep hygiene measures.

What condition does NCT05715866 study?

NCT05715866 studies Alzheimer Disease.

Is NCT05715866 still recruiting?

NCT05715866 is currently completed. Last updated 8 February 2023.

Last reviewed 2023-02-08 · How we verify

NCT05715866

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Non-invasive Stimulation Through Nesa and Therapeutic Exercise on Sleep Disturbances on Alzheimer's Disease Patients.

Completed NA Last updated 8 February 2023

What this trial tests

NA trial testing non-invasive neuromodulation through the Nesa device in Alzheimer Disease in 30 participants. Completed in 22 August 2022.

Timeline

7 December 2021

Primary endpoint
17 June 2022

22 August 2022

Quick facts

Lead sponsor	Universidad de Murcia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	30
Start date	7 December 2021
Primary completion	17 June 2022
Estimated completion	22 August 2022
Sites	2 locations across Spain

Drugs / interventions tested

non-invasive neuromodulation through the Nesa device
therapeutic exercise
sleep hygiene measures

Conditions studied

Alzheimer Disease — all drugs for Alzheimer Disease →

Sponsor

Universidad de Murcia — full company profile →

Who can join

Eligibility, any sex, with Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to know the effectiveness of an adapted therapeutic exercise program and its comparison with non-invasive neuromodulation through the NESA device, and both treatments with a control group, to improve sleep disturbances and cognitive function in patients with dementia, and improves the quality of life of their caregivers.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.
Morrone CD, Raghuraman R, Hussaini SA, Yu WH. · · 2023 · cited 40× · PMID 37085942 · DOI 10.1186/s13024-023-00617-4
Improving Sleep Quality, Daytime Sleepiness, and Cognitive Function in Patients with Dementia by Therapeutic Exercise and NESA Neuromodulation: A Multicenter Clinical Trial.
Teruel-Hernández E, López-Pina JA, Souto-Camba S, Báez-Suárez A, et al · · 2023 · cited 11× · PMID 37947583 · DOI 10.3390/ijerph20217027
The Potential for Neuromodulation in the Treatment of Alzheimer's Disease: A Review of Clinical Trials.
Jones T, Shalom M, Chalamgari A, Gold J, et al · · 2025 · PMID 40599507 · DOI 10.7759/cureus.85156

Verify or expand the search:

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Other Universidad de Murcia trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05715866 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universidad de Murcia
Last refreshed: 8 February 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05715866.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing