NCT05715073 is a NA clinical trial of TeaCrine and Caffeine in Hemodynamics, sponsored by University of South Carolina.

Who is sponsoring NCT05715073?

NCT05715073 is sponsored by University of South Carolina.

What drugs are being tested in NCT05715073?

Interventions in NCT05715073: TeaCrine and Caffeine, Caffeine, Placebo.

What condition does NCT05715073 study?

NCT05715073 studies Hemodynamics, Caffeine, TeaCrine, Cognitive Change.

Is NCT05715073 still recruiting?

NCT05715073 is currently completed. Last updated 29 November 2023.

Last reviewed 2023-11-29 · How we verify

NCT05715073

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Improving Cognition With Neurodegradation Countermeasure

Completed NA Last updated 29 November 2023

What this trial tests

NA trial testing TeaCrine and Caffeine in Hemodynamics in 23 participants. Completed in 1 November 2023.

Timeline

1 March 2023

Primary endpoint
1 November 2023

1 November 2023

Quick facts

Lead sponsor	University of South Carolina
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	other
Enrollment	23
Start date	1 March 2023
Primary completion	1 November 2023
Estimated completion	1 November 2023
Sites	1 location across United States

Drugs / interventions tested

TeaCrine and Caffeine
Caffeine (caffeine) — full drug profile →
Placebo

Conditions studied

Hemodynamics — all drugs for Hemodynamics →
Caffeine — all drugs for Caffeine →
TeaCrine — all drugs for TeaCrine →
Cognitive Change — all drugs for Cognitive Change →

Sponsor

University of South Carolina

Who can join

Adults 18 to 45, any sex, with Hemodynamics or Caffeine. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized, placebo-controlled, three-condition, double-blind, within-participants crossover clinical trial is to compare caffeine, TeaCrine plus caffeine, and a placebo condition in ROTC or tactical personnel. The main question it aims to answer is the effect of the condition on measures of cognitive performance, cardio-autonomic, and hemodynamic responses after a physically demanding protocol. The physiological function will be derived from metrics of heart rate variability, whilst cogntive performance will be evaluated using tasks that assess cognitive domains of executive function, reaction time, and memory. Participants will report to the lab 4 times, once for familiarization of cognitive measures and then 3 times for their experimental visits. Participants will consume their randomized condition an hour prior to the fatiguing interval exercise protocol. Following they will complete a series of cognitive tasks.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions.
Lints BS, Harrison AT, Stray-Gundersen SO, Mastrofini GF, et al · · 2025 · cited 1× · PMID 40693646 · DOI 10.1080/15502783.2025.2536146

Verify or expand the search:

Other recruiting trials for Hemodynamics

Currently open trials in the same condition.

NCT07343843 — Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes Duri · NA · recruiting
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NCT07260890 — Paired Comparison of SVV and PVI Accuracy · recruiting
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Other University of South Carolina trials

Trials by the same sponsor.

NCT06469749 — Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults · NA · not yet recruiting
NCT07340580 — Implementation Facilitation of Exercise is Medicine Greenville · NA · not yet recruiting
NCT07518407 — Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy · NA · not yet recruiting
NCT07340099 — Church Implementation of a Social Support Intervention to Increase Physical Activity in Older African American Adults · NA · not yet recruiting
NCT06024317 — Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05715073 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of South Carolina
Last refreshed: 29 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05715073.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing