NCT05714787

Opportunistic Screening for Osteoporotic Vertebral Fractures in Patients With Diffuse Interstitial Lung Disease

Completed Last updated 1 April 2025

What this trial tests

trial testing Chest CT Scan examination in Osteoporosis in 202 participants. Completed in 1 January 2023.

Timeline

23 January 2017

Primary endpoint
1 January 2023

1 January 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Nice
Status	Completed
Study type	OBSERVATIONAL
Enrollment	202
Start date	23 January 2017
Primary completion	1 January 2023
Estimated completion	1 January 2023
Sites	1 location across France

Drugs / interventions tested

• Chest CT Scan examination

Conditions studied

• Osteoporosis — all drugs for Osteoporosis →
• Interstitial Lung Disease — all drugs for Interstitial Lung Disease →
• Vertebral Fracture — all drugs for Vertebral Fracture →

Sponsor

Centre Hospitalier Universitaire de Nice

Who can join

Adults 18 to 95, any sex, with Osteoporosis or Interstitial Lung Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It is well known that some chronic respiratory pathologies such as asthma or chronic obstructive pulmonary disease (COPD) are associated with an increased risk of osteoporosis, due to the pathology itself and the therapies implemented (per-os or inhaled corticosteroids). Osteoporosis leads to an increased risk of fragility fracture, with an increased morbidity and mortality associated with severe fractures such as vertebral fractures. Also, osteoporotic vertebral fractures often occur at the thoracolumbar hinge, resulting in worsening of the thoracic kyphosis. However, to the best of our knowledge, the prevalence of osteoporotic vertebral fractures measured by CT scan in patients with interstitial lung disease (ILD) is not known. For these patients who already have impaired respiratory function, the appearance of vertebral fractures could impact their management and worsen their prognosis (additional restrictive syndrome, difficulties in analgesics management because of respiratory contraindications, difficulties in wearing a corset, etc...). In this context, it appears interesting to define the prevalence of osteoporosis and osteoporotic vertebral fractures at the thoracic spine and the thoraco-lumbar hinge in a population of patients followed for ILD. So, the main objective of this study is to describe the prevalence of vertebral osteoporotic fractures in an overall cohort of patients with ILD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.