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NCT05709717
Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases
trial testing Regenerative therapy with SVF-PRP to supplement perianal surgery in Perianal Fistula in 50 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Kantonsspital Winterthur KSW |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 25 January 2023 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 January 2024 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Regenerative therapy with SVF-PRP to supplement perianal surgery
Conditions studied
- Perianal Fistula — all drugs for Perianal Fistula →
- Perianal Crohn Disease — all drugs for Perianal Crohn Disease →
- Anal Fissure — all drugs for Anal Fissure →
- Rectovaginal Fistula — all drugs for Rectovaginal Fistula →
Sponsor
Kantonsspital Winterthur KSW — full company profile →
Who can join
16 and older, any sex, with Perianal Fistula or Perianal Crohn Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire. Fistula were drained with setons prior surgery. SVF was harvested from subcutaneous abdominal fat and PRP from peripheral blood. Distal fistulectomy to the sphincter was performed and the wound left open, while the internal orifice was closed. SVF-PRP was injected around the fistula. Patients showered their excision wound until dry. Outcomes were reported as median \& interquartile range (IQR)
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Systematic review and meta-analysis of the efficacy and safety of stem cell treatment of anal fistulas.
Emile SH, Dourado J, Rogers P, Wignakumar A, et al · · 2025 · cited 5× · PMID 40205247 · DOI 10.1007/s10151-025-03138-y -
Addition of Platelet-Rich Plasma to Endorectal Advancement Flap Repair Does Not Enhance the Healing of Cryptoglandular Transsphincteric Fistulas.
Bak MTJ, Bak MTJ, Arkenbosch JHC, Becker MAJ, et al · · 2024 · cited 4× · PMID 38701430 · DOI 10.1097/dcr.0000000000003312
Verify or expand the search:
- PubMed search for NCT05709717
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Perianal Fistula
Currently open trials in the same condition.
- NCT07519850 — The Impact of Perianal Disease on Patient's Sex Life · recruiting
- NCT07477496 — Recurrence and Anal Fistula Patient Reported Outcomes Trial · recruiting
- NCT06446635 — Semiflex Assisted Vacuum Therapy for Perianal Abscesses/Sinuses and Fistula: a Pilot Study · NA · recruiting
Other Kantonsspital Winterthur KSW trials
Trials by the same sponsor.
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- NCT06384053 — Skin Cancer and Hyperthermia and Radiotherapy · NA · recruiting
- NCT06272513 — Influencing Factors for Physical Activity in People With Head and Neck Cancer · completed
- NCT06135402 — Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus · NA · recruiting
- NCT06643325 — Gastric Emptying Time in Traumatic Injuries · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05709717 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kantonsspital Winterthur KSW
- Last refreshed: 2 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05709717.
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