Last reviewed · How we verify
NCT05706181
Heat Therapy, Functional Capacity, and Vascular Health in Older Adults
Phase 1, PHASE2 trial testing Home-based leg heat therapy in Aging Well in 72 participants. Currently enrolling.
30 June 2025
Quick facts
| Lead sponsor | University of North Texas Health Science Center |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 72 |
| Start date | 3 November 2022 |
| Primary completion | 30 June 2025 |
| Estimated completion | 30 July 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Home-based leg heat therapy
- Home-based sham therapy
Conditions studied
- Aging Well — all drugs for Aging Well →
- Walking, Difficulty — all drugs for Walking, Difficulty →
- Hyperemia — all drugs for Hyperemia →
Sponsor
University of North Texas Health Science Center
Who can join
Adults 55 to 80, any sex, with Aging Well or Walking, Difficulty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To test the hypothesis that home-based leg heat therapy improves functional capacity, vascular function, and exercise hyperemia in older adults.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Home-based heat therapy lowers blood pressure and improves endothelial function in older adults.
Ruiz-Pick YI, Cope HL, Richey RE, Moore AM, et al · · 2025 · cited 5× · PMID 40062687 · DOI 10.1152/japplphysiol.00977.2024 -
Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.
Zheng P, Yan W, Ding Y, Zhang Y, et al · · 2026 · PMID 42010239 · DOI 10.1038/s41392-026-02630-7
Verify or expand the search:
- PubMed search for NCT05706181
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Home-based leg heat therapy
Trials testing the same drug.
- NCT05335161 — A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease · Phase 1 · completed
Other recruiting trials for Aging Well
Currently open trials in the same condition.
- NCT06507189 — Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX) · NA · recruiting
- NCT05910619 — Transcranial Pulse Stimulation of the Brain · NA · recruiting
- NCT06204562 — Feasibility and Effects of Laughter-imitation Therapy (LIT) · NA · active not recruiting
- NCT05920733 — Healthy Lifetime - Phase 2 · NA · recruiting
- NCT06217601 — Impact Evaluation of the Digital Connect Project for Homebound Older Adults · NA · active not recruiting
Other University of North Texas Health Science Center trials
Trials by the same sponsor.
- NCT04978129 — Enhancing Quality in Protective Strategies · NA · completed
- NCT06025630 — Targeting Endoplasmic Reticulum Stress in Human Hypertension · Phase 1, PHASE2 · recruiting
- NCT05495087 — IHT for Mild Cognitive Impairment · NA · unknown
- NCT04333966 — Parental Research on Interventions for Social Media · NA · completed
- NCT03750838 — Alcohol Intervention for First Year College Students · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05706181 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of North Texas Health Science Center
- Last refreshed: 13 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05706181.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing