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NCT05700682: MRI
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
trial testing Shoulder/Hip/Knee Embolization with Embozene Microspheres in Osteoarthritis, Knee in 120 participants. Currently enrolling.
1 March 2026
Quick facts
| Lead sponsor | Palo Alto Veterans Institute for Research |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 15 July 2023 |
| Primary completion | 1 March 2026 |
| Estimated completion | 1 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Shoulder/Hip/Knee Embolization with Embozene Microspheres
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
- Osteoarthritis, Hip — all drugs for Osteoarthritis, Hip →
- Osteo Arthritis Shoulders — all drugs for Osteo Arthritis Shoulders →
- Synovitis of Knee — all drugs for Synovitis of Knee →
Sponsor
Palo Alto Veterans Institute for Research
Who can join
Adults 25 to 80, any sex, with Osteoarthritis, Knee or Osteoarthritis, Hip. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05700682
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Palo Alto Veterans Institute for Research trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05700682 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Palo Alto Veterans Institute for Research
- Last refreshed: 7 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05700682.
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