Last reviewed · How we verify
Myocardial Reserve in Advanced Heart Failure Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
Details
| Lead sponsor | University of Chicago |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | RECRUITING |
| Enrolment | 5 |
| Start date | 2023-07-06 |
| Completion | 2026-06 |
Conditions
- Heart Failure
- Cardiogenic Shock
Interventions
- 1:1 Randomization to receive milrinone
Primary outcomes
- Changes in invasive hemodynamics using a pulmonary artery (PA) catheter measuring mmHg — Baseline and 6,12,24,36,72 Hours post-inotrope challenge.
Changes invasive hemodynamics representing myocardial reserve will be measured in 5 patients using a pulmonary artery (PA) catheter: Pulmonary capillary wedge pressure (PCWP mmHg); Right Atrial pressure (RA mmHg); Pulmonary Atrial pressures (PA mmHg); - Changes in invasive hemodynamics using a pulmonary artery (PA) catheter measuring L/min/m2 — Baseline and 6,12,24,36,72 Hours post-inotrope challenge.
Changes invasive hemodynamics representing myocardial reserve will be measured in 5 patients using a pulmonary artery (PA) catheter: Cardiac output by Fick (CO L/min/m2); Cardiac index by Fick (CI L/min/m2). - Advanced heart failure therapy — 2 years
Duration of time without need for definitive advanced heart failure therapy (LVAD, OHT) or death. - Inotropes — 2 years
Duration of time on inotropes during hospitalization - Death — 2 years
Cardiovascular death and/or all-cause mortality - Cardiac output measurement using a pulmonary artery (PA) catheter measuring mmHg at 2 years — 2 years
Efficacy of increasing cardiac output with milrinone compared to dobutamine using changes invasive hemodynamics in 5 patients using a pulmonary artery (PA) catheter: Pulmonary capillary wedge pressure (PCWP mmHg), Right Atrial pressure (RA mmHg), Pulmonary Atrial pressures (PA mmHg),
Countries
United States