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Pilot Observational Study Examining the Effect of Endocrine Therapy on Aging (BETA)
The goal of this pilot observational study is to learn about the feasibility of collecting patient-reported data and stool and blood samples from patients age 65 and older treated with aromatase inhibitor therapy for breast cancer. Participants will be treated with standard of care aromatase inhibitor therapy and will undergo serial phlebotomy, complete patient-reported questionnaires, and submit serial stool samples. The main exploratory translational questions it aims to obtain preliminary data for are: * What are the effects of aromatase inhibitor therapy on biomarkers of aging? * What are the effects of aromatase inhibitor therapy on the microbiome? These data will be used for the development of future definitive studies.
Details
| Lead sponsor | University of Michigan |
|---|---|
| Status | COMPLETED |
| Enrolment | 94 |
| Start date | Mon Jul 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Feb 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Breast Neoplasm Female
- Arthralgia
- Aging
Interventions
- Aromatase inhibitor
Countries
United States