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NCT05695053
Low Level Laser Therapy Applied in Orthodontic Tooth Movement
EARLY_PHASE1 trial testing Low Level Laser Therapy in Orthodontic Appliance Complication in 20 participants. Completed in 26 August 2023.
26 August 2022
Quick facts
| Lead sponsor | China Medical University Hospital |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | device feasibility |
| Enrollment | 20 |
| Start date | 27 August 2021 |
| Primary completion | 26 August 2022 |
| Estimated completion | 26 August 2023 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Low Level Laser Therapy — full drug profile →
- Placebo
Conditions studied
- Orthodontic Appliance Complication — all drugs for Orthodontic Appliance Complication →
Sponsor
China Medical University Hospital
Who can join
18 and older, any sex, with Orthodontic Appliance Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05695053
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05695053 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by China Medical University Hospital
- Last refreshed: 13 February 2025
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