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NCT05694026
Management of DE With IPL in Combination With DQS
NA trial testing Intense pulsed light in Dry Eye in 360 participants. Completed in 1 July 2023.
1 July 2023
Quick facts
| Lead sponsor | He Eye Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 360 |
| Start date | 1 March 2023 |
| Primary completion | 1 July 2023 |
| Estimated completion | 1 July 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Intense pulsed light
- Diquafosol tetrasodium — full drug profile →
Conditions studied
- Dry Eye — all drugs for Dry Eye →
Sponsor
He Eye Hospital
Who can join
Adults 18 to 90, any sex, with Dry Eye. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intense pulsed light (IPL) has been reported to improve signs and symptoms of dry eye (DE). Additionally, meibomian gland secretion of lipids has been observed to improve through the use of IPL. Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells. Therefore, tear film stability and hydration of the ocular surface can be achieved independent from lacrimal glands function. The purpose of this prospective study was to evaluate and compare the effects of IPL (IPL group), DQS (DQS group) and IPL in combination with DQS (IPL+ group) in participants with persistent DE. Tear film lipid layer (TFLL), non-invasive breakup time (NITBUT), tear meniscus height (TMH), corneoconjunctival staining score (CS), meibum gland (MG) function, conjunctival hyperemia (RS score), ocular surface disease index (OSDI) will be assessed and compared at baseline, day-14, and day-28.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study.
Chen J, Qin G, Li L, Qi Y, et al · · 2023 · cited 11× · PMID 37589932 · DOI 10.1007/s40123-023-00784-z -
Human retinal secretome: A cross-link between mesenchymal and retinal cells.
Donato L, Scimone C, Alibrandi S, Scalinci SZ, et al · · 2023 · cited 6× · PMID 37545752 · DOI 10.4252/wjsc.v15.i7.665 -
Protocol for a parallel assignment prospective, randomised, comparative trial to evaluate the safety and efficacy of intense pulsed light (IPL) combined with 3% diquafosol (DQS) ophthalmic solution in dry eye syndrome.
Chen J, Qin G, Li L, Qi Y, et al · · 2023 · cited 4× · PMID 37643847 · DOI 10.1136/bmjopen-2023-073055
Verify or expand the search:
- PubMed search for NCT05694026
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intense pulsed light
Trials testing the same drug.
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- NCT06745089 — Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye · NA · completed
- NCT06034626 — Therapeutic Effectiveness of Different Machines in Intense Pulsed Light Treatment of Meibomian Gland Dysfunction · Phase 3 · completed
Other recruiting trials for Dry Eye
Currently open trials in the same condition.
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Other He Eye Hospital trials
Trials by the same sponsor.
- NCT07097922 — Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients With Dry Eye After LASIK · NA · not yet recruiting
- NCT06852105 — Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients with Dry Eye After Trans-PRK · NA · not yet recruiting
- NCT06714994 — Effect of Spectacle Distribution to Myopic Secondary School Students in Rural Communities of Liaoning Province on Commun · NA · not yet recruiting
- NCT06656403 — Effect of Artificial Tears on Ocular Biometry Parameters · NA · not yet recruiting
- NCT06537349 — Effects of 3% Diquafosol on Tear Film and Vision-related Quality of Life in Orthokeratology Lens Related Dry Eye · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05694026 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by He Eye Hospital
- Last refreshed: 25 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05694026.
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