NCT05690061

Beef and Plant Burger Metabolomics Study

Active, enrolled NA Last updated 30 April 2024

What this trial tests

NA trial testing Grain-Fed Beef Hamburger in Inflammatory Response in 36 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2023

Primary endpoint
23 December 2023

16 December 2024

Quick facts

Lead sponsor	Utah State University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	36
Start date	1 February 2023
Primary completion	23 December 2023
Estimated completion	16 December 2024
Sites	1 location across United States

Drugs / interventions tested

• Grain-Fed Beef Hamburger
• Grass-Fed Beef Hamburger
• Impossible BurgerTM

Conditions studied

• Inflammatory Response — all drugs for Inflammatory Response →

Sponsor

Utah State University

Who can join

Adults 30 to 60, any sex, with Inflammatory Response. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the effects of meat on inflammatory and metabolite profiles in middle-aged individuals after an acute meal. Up to 36 adults, who are overweight or obese and between 30-60 years old will undergo a consent/screening visit, followed by three study visits. On separate visits to the clinical research facilities at the Center for Human Nutrition Studies, participants will consume either 9 oz (250 grams) of cooked grain-fed beef, grass-fed beef, or a plant-based meat alternative (Impossible Burger). Blood will be drawn prior to food consumption and three more times after eating the meal at 1h, 3h, and 5h after participants finishing their meal. The investigators will use those blood samples to determine the impacts of these foods on inflammatory markers and metabolite profiles (compounds that circulate in our blood such as amino acids, fatty acids, and phenolics).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparing postprandial inflammatory responses to a plant-based meat alternative, grass-finished beef, and grain-finished beef in healthy middle-aged adults: a 3-group randomized crossover trial.
   Cloward J, Mason O, DeJesus I, Broadbent J, et al · · 2026 · PMID 41519303 · DOI 10.1016/j.ajcnut.2026.101192