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NCT05682924
Condition Vasoregulation Function Endothelium in Patients With CML Getting TKI II Generation Bosutinib
trial testing taking blood for the study of biochemical parameters and the study of microcirculation using the method of laser Doppler flowmetry in Chronic Myeloid Leukaemia in 105 participants. Currently enrolling.
1 September 2025
Quick facts
| Lead sponsor | Samara State Medical University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 105 |
| Start date | 1 October 2022 |
| Primary completion | 1 September 2025 |
| Estimated completion | 15 September 2025 |
| Sites | 2 locations across Russia |
Drugs / interventions tested
- taking blood for the study of biochemical parameters and the study of microcirculation using the method of laser Doppler flowmetry
Conditions studied
- Chronic Myeloid Leukaemia — all drugs for Chronic Myeloid Leukaemia →
Sponsor
Samara State Medical University
Who can join
Adults 40 to 60, any sex, with Chronic Myeloid Leukaemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study will study the state of the endothelium in patients with chronic myeloid leukemia during therapy with the II generation tyrosine kinase inhibitor bosutinib. Patients will be divided into groups receiving nilotinib 800mg/day, bosutinib 500mg/day, and imatinib 600mg/day. A comprehensive examination of patients will be carried out, including a clinical examination, a study of biochemical markers of endothelial damage and the functional state of the vascular wall. An algorithm will be developed for assessing the state of endothelial function in patients with ph-positive chronic myeloid leukemia in the chronic phase when using the second-generation tyrosine kinase inhibitor bosutinib.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05682924
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05682924 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Samara State Medical University
- Last refreshed: 16 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05682924.
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