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NCT05679102

Atorvastatin as an Antihypertensive Agent

Completed NA Last updated 10 January 2023
What this trial tests

NA trial testing Amlodipine 5 MG Oral Tablet in Atorvastatin Antihypertensive Effect in 120 participants. Completed in 4 January 2023.

Timeline
20 December 2022
Primary endpoint
4 January 2023
4 January 2023

Quick facts

Lead sponsorHimayat Ullah
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment120
Start date20 December 2022
Primary completion4 January 2023
Estimated completion4 January 2023
Sites1 location across Saudi Arabia

Drugs / interventions tested

Conditions studied

Sponsor

Himayat Ullah — full company profile →

Who can join

35 and older, any sex, with Atorvastatin Antihypertensive Effect. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is aimed to see the antihypertensive effect of statin (Atorvastatin) as certain animal models have shown that statins have the voltage-gated calcium channel blocking effect. It will be a randomized controlled trial that will be done in Ayub Hospital Complex Abbottabad. After ethical approval, 120 patients with newly diagnosed hypertension belonging to either gender and aged 35 and above will be enrolled in the trial. They will randomly be grouped into two groups with each group comprising 60 patients. One group will be administered Amlodipine 5 mg PO once a day, while the other one will be given 5mg Amlodipine plus 10 mg Atorvastatin. The patients will be examined on a follow-up visit 14 days later and blood pressure will be recorded as per protocols.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Atorvastatin as an Antihypertensive Agent: A Pilot Study.
    Ali N, Faheem M, Ullah H, Shabana H, et al · · 2023 · cited 1× · PMID 38156151 · DOI 10.7759/cureus.49532

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