Last reviewed · How we verify
NCT05678218: POELH-II
Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma
trial testing Endoscopic Ultrasound registration in Hilar Cholangiocarcinoma in 245 participants. Completed in 1 August 2025.
1 July 2025
Quick facts
| Lead sponsor | Erasmus Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 245 |
| Start date | 5 September 2022 |
| Primary completion | 1 July 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 7 locations across Belgium, Netherlands |
Drugs / interventions tested
- Endoscopic Ultrasound registration
Conditions studied
- Hilar Cholangiocarcinoma — all drugs for Hilar Cholangiocarcinoma →
- Intrahepatic Cholangiocarcinoma — all drugs for Intrahepatic Cholangiocarcinoma →
- Common Bile Duct Neoplasms — all drugs for Common Bile Duct Neoplasms →
- Cholangiocarcinoma — all drugs for Cholangiocarcinoma →
Sponsor
Erasmus Medical Center
Who can join
Adults 18 to 110, any sex, with Hilar Cholangiocarcinoma or Intrahepatic Cholangiocarcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational cohort study is to assess the yield of preoperative endoscopic ultrasound focussed on lymph nodes in patients with presumed resectable perihilar (pCCA), intrahepatic (iCCA) or mid-common bile duct (CBD) cholangiocarcinoma. The main questions it aims to answer is: 1. The number of patients precluded from surgical work-up due to positive regional or extraregional lymph nodes identified by endoscopic ultrasound guided tissue acquisition 2. Characteristics during endoscopic ultrasound of lymph nodes associated with malignancy
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Endoscopic ultrasound with tissue acquisition of lymph nodes in patients with potentially resectable intrahepatic cholangiocarcinoma.
de Jong DM, van de Vondervoort S, Dwarkasing RS, Thomeer MGJ, et al · · 2024 · cited 3× · PMID 39184062 · DOI 10.1055/a-2366-2592 -
Endoscopic Ultrasound for Nodal Staging in Patients with Resectable Cholangiocarcinoma.
de Jong DM, van Driel LMJW, Lakhtakia S, Ramchandani M, et al · · 2025 · cited 2× · PMID 41226941 · DOI 10.3390/jcm14217545 -
Interobserver variability in lymph node evaluation with endoscopic ultrasonography in cholangiocarcinoma.
de Jong DM, Roosterman D, Bruno MJ, van Driel LMJW, et al · · 2025 · cited 1× · PMID 40376023 · DOI 10.1055/a-2577-5449 -
UEG Week 2024 Moderated Posters
· 2024 -
UEG Week 2023 Moderated Posters
· 2023
Verify or expand the search:
- PubMed search for NCT05678218
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hilar Cholangiocarcinoma
Currently open trials in the same condition.
- NCT06717464 — Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepa · Phase 2 · active not recruiting
- NCT07176962 — A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening · recruiting
Other Erasmus Medical Center trials
Trials by the same sponsor.
- NCT07406269 — Clinical Evaluation of AI Decision Support for Early Rehabilitation After Surgery · NA · not yet recruiting
- NCT07402109 — CBCT Guided Markerless SBRT for Renal Cell Cancer · NA · recruiting
- NCT07383194 — Prediction Models for LDLT Outcomes · not yet recruiting
- NCT07426575 — Evaluating the Usability of New Dialysis Bags · not yet recruiting
- NCT07329296 — The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05678218 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Erasmus Medical Center
- Last refreshed: 8 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05678218.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing